Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
about
RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNSSex-dependent treatment of chronic EAE with partial MHC class II constructs.Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.Characterization of human platelet binding of recombinant T cell receptor ligand.Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in miceMyelin specific cells infiltrate MCAO lesions and exacerbate stroke severity.Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice.Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study.Systemic immunotherapy delays photoreceptor cell loss and prevents vascular pathology in Royal College of Surgeons rats.Effective Arrestin-Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis.Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules.
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Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Recombinant T cell receptor li ...... therapy for multiple sclerosis
@en
Recombinant T cell receptor li ...... herapy for multiple sclerosis.
@nl
type
label
Recombinant T cell receptor li ...... therapy for multiple sclerosis
@en
Recombinant T cell receptor li ...... herapy for multiple sclerosis.
@nl
prefLabel
Recombinant T cell receptor li ...... therapy for multiple sclerosis
@en
Recombinant T cell receptor li ...... herapy for multiple sclerosis.
@nl
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Recombinant T cell receptor li ...... therapy for multiple sclerosis
@en
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Arthur A Vandenbark
Chunhe Wang
Gregory G Burrows
Halina Offner
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P304
P356
10.1515/REVNEURO.2008.19.4-5.327
P577
2008-01-01T00:00:00Z