The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease - Wikidata - wikimedia - TriplyDB

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

http://www.wikidata.org/entity/Q37071213

about

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond PGC-1α, mitochondrial dysfunction, and Huntington's disease Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?NMDA receptor gene variations as modifiers in Huntington disease: a replication study Shaping the role of mitochondria in the pathogenesis of Huntington's disease Mitochondrial dysfunction in neurodegenerative diseases Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.Modeling Huntington disease in yeast: perspectives and future directions.Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation.A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients.Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease.The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease.A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver.Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease.Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases.Foxa1 is essential for development and functional integrity of the subthalamic nucleus.β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging.Molecular mechanisms and potential therapeutical targets in Huntington's disease.PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond.Targeting Huntington's disease through histone deacetylases.Prospects for neuroprotective therapies in prodromal Huntington's disease.

P2860

Q22306292-B06F71B1-F270-4B05-A0B4-5A8CA0C94D43 Q26823365-2CBF1ED7-AC75-4131-B532-18065625068A Q26996576-452B65A9-F5AA-43A4-85D8-9980445424F7 Q27001671-178859C3-4F5A-4ED5-87ED-3E54B0548BB9 Q27011387-FD15EE0E-A279-4CA6-AD7D-0017B2116B35 Q27499977-9145E95D-59ED-4727-89BE-8ADE08B6906C Q28384036-CE6BFD7C-79F5-41E9-B9EA-3256ED67C03C Q28387647-E299BCE4-3B52-49EF-8A1D-0AA370930C6C Q28587748-8161A983-920F-4A1B-9D96-B50FC99A05F8 Q30424048-780FAC69-7E8F-44A9-8643-14FAE7D4D988 Q33575494-A3BC2FFB-CFB8-4B0A-912B-7CCEF9629297 Q33906098-1B9C17D3-71FD-4A03-9523-1A0B4827C5E9 Q34042260-CE33D784-88DD-4473-8108-6C6A3BFD2939 Q34275231-103A5DE2-EC04-43BF-8722-FD4C85D1CF46 Q34312581-68FEFF23-26B9-488D-A09A-9E7206756D05 Q34319766-7EF9C41C-7351-4472-AE41-528273880BD4 Q34383492-3311E26B-2FF7-4FF1-A706-F8E1FDF2A414 Q34391101-58C4CF7E-EBDD-48A2-8D0E-2FD973E53C12 Q34473733-22D4F75A-E8F6-45E8-997F-C5939349EAB8 Q34498391-23172CF0-74EC-4743-AAEE-8597A4EA3B3B Q34873673-A297AB0C-8A7A-45B0-BA15-A5205216A4A0 Q34944325-38079BA4-F1F2-4C9A-A8BE-A29F7E583773 Q35052819-612C6174-5781-4145-91B9-E37BC7BD64E8 Q35079574-70704D4C-9FF8-4E61-B578-D550E5EDD6B4 Q35604515-F9E8A514-D477-4212-A1A7-2D549482B6E4 Q35684210-1372CAC9-11C6-45EA-A9D5-F4929389F357 Q35750228-29596CAB-DD4C-45E8-91D9-33BD1F5C63CB Q35856269-9ECE7775-7855-4859-98E4-DD0EC9BEA258 Q36771650-4F138BEB-4E8B-49F6-A0E8-76713D1B21CD Q37093737-35E7DB41-A965-47E7-9022-5871FE5A6641 Q37368003-23ED7824-DBBA-49E2-AE83-B53A6F69F0A6 Q37382205-8097494C-B0B6-409D-928C-3759CCAD62D1 Q37488064-64D8EBB9-40AF-4AA3-9646-D10C63107011 Q37603963-2B013623-CBBE-46A0-8868-C90D5BEB0371 Q37689883-5CAF6BD9-5C80-48F0-BF6F-6D2A92E124A2 Q37698147-6EDA02A0-39B7-4643-935F-06D68A7E5F23 Q37776087-1103E614-9225-4EAB-81CD-5FEF802270EE Q37958488-9781D389-0DA0-4409-9A6C-3EAEFAA51046 Q38019159-229DFCA7-9036-4258-B265-E3713EDDA9FD Q38191477-AE60EC11-9550-4906-A1E2-347D6EF64312

P2860

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

http://www.wikidata.org/entity/Q37071213

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 08 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

@en

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.

@nl

type

label

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

@en

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.

@nl

prefLabel

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

@en

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.

@nl

P1433

Q37071213-16061231-1CC2-44D1-A9C9-B9764C99AA89

P1476

Q37071213-AA35A5BD-B8ED-443B-A0B7-9A74FEF52448

P2093

Q37071213-1CB5E323-B08E-457F-9C2C-453C0AC35ACF

Q37071213-22507082-B10E-4AF1-8990-A24A12AA6559

Q37071213-31803AAD-1151-40F2-81A5-77EA923BB6CC

Q37071213-90303FD8-B029-426F-8B07-7FBE2C5F4FE6

Q37071213-B6B3C9D3-36F6-4816-B963-A3008FB92C44

Q37071213-DFF97D9E-C88A-4FED-A3FD-BEE38C9A1188

Q37071213-E4B23089-5DD0-4592-8E5E-42E1D3AD8B50

P2860

Q37071213-04F513DB-DF31-45A5-ABBA-1C2EC3C74650

Q37071213-06BE1B63-62BF-4F02-916F-C42B2E701A21

Q37071213-0972F83D-2DBB-494F-AC87-B649FA216F0E

Q37071213-1B5A671D-C370-4794-B183-96853A3DF929

Q37071213-27D16751-1B61-4E99-8C7F-A7BA1E031248

Q37071213-32AEA041-7782-4950-A38E-BDEDD14361C6

Q37071213-3C8C9034-28DE-466E-8859-4FC7038E1B84

Q37071213-3E54D69A-81BE-40B0-9FFA-6FE927AA0C63

Q37071213-52F4785B-E81A-48E3-A397-C9ADAE0819D6

Q37071213-5C8291A6-21AD-4D99-A5DF-DA029AAECEA7

P2888

Q37071213-670B911D-56A4-40B9-AF6F-725428C10FCC

P304

Q37071213-BAEF5CF2-619B-4BA0-A074-7747D684C5F7

P31

Q37071213-4F8EA39A-EB66-4128-9E0B-067A02C93615

P356

Q37071213-545AA898-4473-491B-9FEE-898CC3B70210

P478

Q37071213-9C360955-CBE0-49ED-9EC5-0463E4C34DA9

P50

Q37071213-30350824-3014-4D13-AB41-40679F5253A1

P577

Q37071213-A8664BF5-7E20-474C-AB94-1788285243C2

P5875

Q37071213-565DC177-B598-41C7-BB44-D0DA9914640D

P6179

Q37071213-641B8CE7-D455-49EF-9E2C-88C457A46F5F

P698

Q37071213-189542DA-C37F-4691-B573-1A1DE49D2567

P921

Q37071213-60A65B5A-62FB-4255-BB78-BA11D3F7204E

P932

Q37071213-4ADCECAA-AD92-4218-9DD9-7063E6ACF14B

P356

P1433

Molecular Neurodegeneration

P1476

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

@en

P2093

Claus Weidinger

http://www.w3.org/2001/XMLSchema#string

G Bernhard Landwehrmeyer

http://www.w3.org/2001/XMLSchema#string

Hannes Oberkofler

http://www.w3.org/2001/XMLSchema#string

Patrick Weydt

http://www.w3.org/2001/XMLSchema#string

Selma M Soyal

http://www.w3.org/2001/XMLSchema#string

Stefano Didonato

http://www.w3.org/2001/XMLSchema#string

Wolfgang Patsch

http://www.w3.org/2001/XMLSchema#string

P2860

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

Huntington's disease

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

Score tests for association between traits and haplotypes when linkage phase is ambiguous

Metabolic control through the PGC-1 family of transcription coactivators

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

P2888

P304

3

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1750-1326-4-3

http://www.w3.org/2001/XMLSchema#string

P478

4

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-01-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23767892

http://www.w3.org/2001/XMLSchema#string

P6179

1052726702

http://www.w3.org/2001/XMLSchema#string

P698

19133136

http://www.w3.org/2001/XMLSchema#string

P921

Huntington disease

P932

2630305

http://www.w3.org/2001/XMLSchema#string