Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q37073099

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Drug and gene delivery across the blood-brain barrier with focused ultrasound ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route.Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction.Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease.Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration.Microdomains, Inflammation, and Atherosclerosis.Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators.Gene therapy for neurological disorders.Viral vectors for therapy of neurologic diseases.Adenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy.Cellular Cholesterol Homeostasis in Alzheimer's Disease.Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease.Inducible and combinatorial gene manipulation in mouse brain.Acyl-coenzyme A:cholesterol acyltransferase 1 - significance of single-nucleotide polymorphism at residue 526 and the role of Pro347 near the fifth transmembrane domain.Intracellular Cholesterol Trafficking and Impact in Neurodegeneration.Nucleic Acid-Based Theranostics for Tackling Alzheimer's Disease.Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing

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Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q37073099

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 18 June 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@en

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@nl

type

label

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@en

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@nl

prefLabel

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@en

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@nl

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Molecular Therapy

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Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

@en

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Catherine Cy Chang

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Elena Y Bryleva

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Godwin Dogbevia

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Mazahir T Hasan

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Stephanie R Murphy

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Ta-Yuan Chang

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Zachary Bowen

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P2860

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

Alzheimer mechanisms and therapeutic strategies

Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress

Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.

Silencing and un-silencing of tetracycline-controlled genes in neurons

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1497-1506

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scholarly article

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10.1038/MT.2013.118

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8

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21

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2013-06-18T00:00:00Z

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23774792

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Alzheimer's disease

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3734664

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