Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
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EZH2 in Bladder Cancer, a Promising Therapeutic TargetEpigenetic regulation of endothelial-cell-mediated vascular repairSynergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb ActivationRole of EZH2 in cancer stem cells: from biological insight to a therapeutic target.Chromatin proteins and modifications as drug targets.Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.EZH2 as a potential target in cancer therapy.Histone methylases as novel drug targets: developing inhibitors of EZH2.Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growthTET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissuesMulticellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs.Targeting epigenetic regulations in cancer3D culture adds an extra dimension to targeted epigenetic therapiesTargeting EZH2 for cancer therapy: progress and perspective.EZH2 is required for mouse oocyte meiotic maturation by interacting with and stabilizing spindle assembly checkpoint protein BubRI.Neighborhood matters: response to EZH2 methyltransferase inhibitors.EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells.Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cellsRoles of enhancer of zeste homolog 2: from skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro.Targeting of cancer stem cells by inhibitors of DNA and histone methylation.Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.Structure of the PRC2 complex and application to drug discovery.EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma.Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cellsThe EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells.Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of β-catenin.Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes.Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential.Epigenetic effects of chromatin remodeling agents on organotypic cultures.
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Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Three-dimensional culture sens ...... 2 methyltransferase inhibition
@en
Three-dimensional culture sens ...... methyltransferase inhibition.
@nl
type
label
Three-dimensional culture sens ...... 2 methyltransferase inhibition
@en
Three-dimensional culture sens ...... methyltransferase inhibition.
@nl
prefLabel
Three-dimensional culture sens ...... 2 methyltransferase inhibition
@en
Three-dimensional culture sens ...... methyltransferase inhibition.
@nl
P2093
P2860
P356
P1433
P1476
Three-dimensional culture sens ...... 2 methyltransferase inhibition
@en
P2093
Azat Garipov
David W Speicher
Jose R Conejo-Garcia
Michael D Amatangelo
Rugang Zhang
P2860
P304
P356
10.4161/CC.25163
P577
2013-06-10T00:00:00Z