SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis - Wikidata - wikimedia - TriplyDB

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

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Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis The role of IDO in brain tumor immunotherapy SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines AhR-Mediated, Non-Genomic Modulation of IDO1 Function IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy.The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.Aryl hydrocarbon receptor control of a disease tolerance defence pathway An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.IDO is a nodal pathogenic driver of lung cancer and metastasis development.Indoleamine 2,3 dioxygenase and metabolic control of immune responses.Tryptophan-catabolizing enzymes - party of three Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.Tryptophan-degrading enzymes in tumoral immune resistance.Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases.Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8 Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3)Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins.Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy.Indoleamine 2,3-dioxygenase: is it an immune suppressor?Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques.Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases.The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells.Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.SOCS3, a Major Regulator of Infection and Inflammation.Role of IDO in organ transplantation: promises and difficulties.A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.Posttranslational modification of indoleamine 2,3-dioxygenase.Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase.Indoleamine 2,3-dioxygenase: from catalyst to signaling function.

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SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

http://www.wikidata.org/entity/Q37081582

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 December 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

SOCS3 drives proteasomal degra ...... es IDO-dependent tolerogenesis

@en

SOCS3 drives proteasomal degra ...... s IDO-dependent tolerogenesis.

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type

label

SOCS3 drives proteasomal degra ...... es IDO-dependent tolerogenesis

@en

SOCS3 drives proteasomal degra ...... s IDO-dependent tolerogenesis.

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prefLabel

SOCS3 drives proteasomal degra ...... es IDO-dependent tolerogenesis

@en

SOCS3 drives proteasomal degra ...... s IDO-dependent tolerogenesis.

@nl

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PNAS.0810278105

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Proceedings of the National Academy of Sciences of the United States of America

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SOCS3 drives proteasomal degra ...... es IDO-dependent tolerogenesis

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Carmine Vacca

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Ciriana Orabona

http://www.w3.org/2001/XMLSchema#string

Claudia Volpi

http://www.w3.org/2001/XMLSchema#string

Francesca Fallarino

http://www.w3.org/2001/XMLSchema#string

Maria C Fioretti

http://www.w3.org/2001/XMLSchema#string

Maria L Belladonna

http://www.w3.org/2001/XMLSchema#string

Maria T Pallotta

http://www.w3.org/2001/XMLSchema#string

Paolo Puccetti

http://www.w3.org/2001/XMLSchema#string

Roberta Bianchi

http://www.w3.org/2001/XMLSchema#string

Ursula Grohmann

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P2860

Prevention of allogeneic fetal rejection by tryptophan catabolism

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

IDO expression by dendritic cells: tolerance and tryptophan catabolism

Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains.

Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

Immune inhibitory receptors.

ITAMs versus ITIMs: striking a balance during cell regulation.

Steady-state and inflammatory dendritic-cell development.

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.

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20828-20833

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scholarly article

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10.1073/PNAS.0810278105

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52

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105

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2008-12-16T00:00:00Z

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23669131

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19088199

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2634889

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