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Interleukin-2 receptor signaling: at the interface between tolerance and immunityPharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitroT cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantationSystemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung.Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis).Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.Serial progression of cortical and medullary thymic epithelial microenvironments.Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection.Seeing is believing: illuminating the source of in vivo interleukin-7.Emerging strategies to boost thymic functionThe Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual BlockadeIntrathymic IL-7: the where, when, and why of IL-7 signaling during T cell developmentRole of Hedgehog signalling at the transition from double-positive to single-positive thymocyteHigh levels of IL-7 cause dysregulation of thymocyte development.Targeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy.Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.Affinity maturation of antibodies requires integrity of the adult thymusIL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7RIL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches.A roadmap for thymic epithelial cell development.IL-7-producing stromal cells are critical for lymph node remodelingFinding their niche: chemokines directing cell migration in the thymus.Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation.Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again.IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasisInterleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.Development and developmental potential of cortical thymic epithelial cells.Generation of diversity in thymic epithelial cells.Cytokines, Transcription Factors, and the Initiation of T-Cell Development.Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis.Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5.Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice.Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes.Ovarian hormone withdrawal in prepubertal developmental stage does not prevent thymic involution in rats.Thymic epithelial β-catenin is required for adult thymic homeostasis and function.Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen.Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Characterization of the thymic IL-7 niche in vivo.
@en
Characterization of the thymic IL-7 niche in vivo.
@nl
type
label
Characterization of the thymic IL-7 niche in vivo.
@en
Characterization of the thymic IL-7 niche in vivo.
@nl
prefLabel
Characterization of the thymic IL-7 niche in vivo.
@en
Characterization of the thymic IL-7 niche in vivo.
@nl
P2093
P2860
P50
P356
P1476
Characterization of the thymic IL-7 niche in vivo
@en
P2093
Allison Bordack
Ana Cumano
Ana Patricia Sousa
Francina Langa Vives
Odile Richard-Le Goff
Richard Boyd
Vera S G Ribeiro
P2860
P304
P356
10.1073/PNAS.0809559106
P407
P577
2009-01-21T00:00:00Z