IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.

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Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy.The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments.Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent.Developmental and Functional Control of Natural Killer Cells by Cytokines.Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells.The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.Leveraging natural killer cells for cancer immunotherapy.Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824).Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy.Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis.Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation.Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control.The potential and promise of IL-15 in immuno-oncogenic therapies.Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas.Regulatory T cells (Tregs): A major immune checkpoint to consider in combinatorial therapeutic HIV-1 vaccines.Complex role of NK cells in regulation of oncolytic virus-bortezomib therapy.Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types Quick efficacy seeking trial (QuEST1): a novel combination immunotherapy study designed for rapid clinical signal assessment metastatic castration-resistant prostate cancer

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P2860

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.

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scientific article published on 18 February 2016

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