Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo.
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VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageNuclear assembly as a target for anti-cancer therapiesThe Warburg effect revisited--lesson from the Sertoli cellLuteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage responseEWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition.Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomesDeletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2.Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase.Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.VRK1 promotes cisplatin resistance by up-regulating c-MYC via c-Jun activation and serves as a therapeutic target in esophageal squamous cell carcinoma.Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiationImplication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells
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Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 June 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
Molecular genetic analysis of ...... growth and metastasis in vivo.
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Molecular genetic analysis of ...... growth and metastasis in vivo.
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type
label
Molecular genetic analysis of ...... growth and metastasis in vivo.
@en
Molecular genetic analysis of ...... growth and metastasis in vivo.
@nl
prefLabel
Molecular genetic analysis of ...... growth and metastasis in vivo.
@en
Molecular genetic analysis of ...... growth and metastasis in vivo.
@nl
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P356
P1433
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Molecular genetic analysis of ...... growth and metastasis in vivo.
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P2093
P Traktman
T P Molitor
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P2888
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10.1038/ONCSIS.2013.11
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2013-06-03T00:00:00Z
P5875
P6179
1044172579