Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity
about
Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Integrity of the Saccharomyces cerevisiae Rpn11 protein is critical for formation of proteasome storage granules (PSG) and survival in stationary phase.Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearanceBase-CP proteasome can serve as a platform for stepwise lid formationNegative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.Human cytomegalovirus UL76 elicits novel aggresome formation via interaction with S5a of the ubiquitin proteasome system.Structural insights into proteasome activation by the 19S regulatory particle.
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P2860
Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Synthetic lethality of rpn11-1 ...... oteasome assembly and activity
@en
Synthetic lethality of rpn11-1 ...... teasome assembly and activity.
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type
label
Synthetic lethality of rpn11-1 ...... oteasome assembly and activity
@en
Synthetic lethality of rpn11-1 ...... teasome assembly and activity.
@nl
prefLabel
Synthetic lethality of rpn11-1 ...... oteasome assembly and activity
@en
Synthetic lethality of rpn11-1 ...... teasome assembly and activity.
@nl
P2093
P2860
P1433
P1476
Synthetic lethality of rpn11-1 ...... oteasome assembly and activity
@en
P2093
Abhishek Chandra
Kiran Madura
P2860
P2888
P304
P356
10.1007/S00294-010-0321-3
P577
2010-10-13T00:00:00Z