Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain.
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Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensingAberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing lossAn electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.ATP-mediated cell-cell signaling in the organ of Corti: the role of connexin channels.Post-translational modifications of connexin26 revealed by mass spectrometry.Transmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1).Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndromeVoltage regulation of connexin channel conductance.Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininiumMolecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gatingThe First Extracellular Domain Plays an Important Role in Unitary Channel Conductance of Cx50 Gap Junction Channels.Voltage-dependent conformational changes in connexin channelsGlutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules.Structural basis for the selective permeability of channels made of communicating junction proteins.Accessing gap-junction channel structure-function relationships through molecular modeling and simulationsThe NH2 terminus regulates voltage-dependent gating of CALHM ion channels.Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances.Functional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32.The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions.Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).Antibodies targeting extracellular domain of connexins for studies of hemichannelsSyndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates.Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel.A history of gap junction structure: hexagonal arrays to atomic resolution.Functional effects of Cx50 mutations associated with congenital cataracts.ATP-induced morphological changes in supporting cells of the developing cochlea.Structure of the gap junction channel and its implications for its biological functions.Spontaneous high-frequency action potential.Paracrine signaling through plasma membrane hemichannelsConnexin channel modulators and their mechanisms of action.Extracellular domains play different roles in gap junction formation and docking compatibility.Structure and closure of connexin gap junction channels.Carbon monoxide: A new player in the redox regulation of connexin hemichannels.Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca²⁺: insight from a local quantum chemistry study.Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
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Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Loop gating of connexin hemich ...... rst extracellular loop domain.
@en
Loop gating of connexin hemich ...... rst extracellular loop domain.
@nl
type
label
Loop gating of connexin hemich ...... rst extracellular loop domain.
@en
Loop gating of connexin hemich ...... rst extracellular loop domain.
@nl
prefLabel
Loop gating of connexin hemich ...... rst extracellular loop domain.
@en
Loop gating of connexin hemich ...... rst extracellular loop domain.
@nl
P2093
P2860
P356
P1476
Loop gating of connexin hemich ...... rst extracellular loop domain.
@en
P2093
Clio Rubinos
Maria P Trelles
Miduturu Srinivas
Thaddeus A Bargiello
Vytas K Verselis
P2860
P304
P356
10.1074/JBC.M807430200
P407
P577
2008-12-11T00:00:00Z