Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3.
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Complement and dysbiosis in periodontal diseasePrevalence, biogenesis, and functionality of the serine protease autotransporter EspPPeriodontitis: from microbial immune subversion to systemic inflammationEspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5.The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elementsInactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent MannerNecrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms.Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss.Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermediaPathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils.Staphylococcal proteases aid in evasion of the human complement system.The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes.Role of complement in host-microbe homeostasis of the periodontium.Comparative genome analysis of Prevotella intermedia strain isolated from infected root canal reveals features related to pathogenicity and adaptation.Polymicrobial synergy and dysbiosis in inflammatory disease.Pathogenic microbes and community service through manipulation of innate immunityImmune evasion strategies of Porphyromonas gingivalis.Early Cytokine Response to Infection with Pathogenic vs Non-Pathogenic Organisms in a Mouse Model of Endodontic Infection.Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola / Prevotella intermedia Co-Infection Are Associated with Severe Periodontitis in a Thai Population.A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system.Complement factors C1q, C3 and C5b-9 in the posterior sclera of guinea pigs with negative lens-defocused myopia.A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement SystemGenomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals.Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritisPorphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosisSelective photoantisepsis.Protease-dependent mechanisms of complement evasion by bacterial pathogens.Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention.Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis.Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host.Complement and periodontitis.New insights into Prevotella diversity and medical microbiology.The complement system and its role in the pathogenesis of periodontitis: current concepts.Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function.Ecological Therapeutic Opportunities for Oral Diseases.
P2860
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P2860
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Interpain A, a cysteine protei ...... egrading complement factor C3.
@en
Interpain A, a cysteine protei ...... egrading complement factor C3.
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type
label
Interpain A, a cysteine protei ...... egrading complement factor C3.
@en
Interpain A, a cysteine protei ...... egrading complement factor C3.
@nl
prefLabel
Interpain A, a cysteine protei ...... egrading complement factor C3.
@en
Interpain A, a cysteine protei ...... egrading complement factor C3.
@nl
P2093
P2860
P50
P1433
P1476
Interpain A, a cysteine protei ...... egrading complement factor C3.
@en
P2093
Katarzyna Popadiak
Katarzyna Wawrzonek
Michal Potempa
Sigrun Eick
Surya P Manandhar
Tomasz Kantyka
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000316
P577
2009-02-27T00:00:00Z