Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes - Wikidata - wikimedia - TriplyDB

Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes

Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes

http://www.wikidata.org/entity/Q37099704

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Hexokinase activity is required for recruitment of parkin to depolarized mitochondria Is REDD1 a Metabolic Éminence Grise?Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming Mitochondrial and postmitochondrial survival signaling in cancer.Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins.SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.IGF1 regulates PKM2 function through Akt phosphorylation Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1 The role of hexokinase in cardioprotection - mechanism and potential for translation.Hexokinases and cardioprotection.A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways.Signal transduction in cancer The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.Signaling Pathways in Cardiac Myocyte Apoptosis.Mitochondrial autophagy in cardiomyopathy.Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes The PI3K pathway in B cell metabolism Mitochondrial Ca2+ and regulation of the permeability transition pore.Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.Mitochondrial determinants of cancer health disparities.The role of succinate and ROS in reperfusion injury - A critical appraisal.Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.The PI3K Pathway in Human Disease.Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity.In vivo PET imaging with [(18)F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes.Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects.Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult.FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells.

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Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes

http://www.wikidata.org/entity/Q37099704

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 08 July 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Akt phosphorylates HK-II at Th ...... tion to protect cardiomyocytes

@en

Akt phosphorylates HK-II at Th ...... ion to protect cardiomyocytes.

@nl

type

label

Akt phosphorylates HK-II at Th ...... tion to protect cardiomyocytes

@en

Akt phosphorylates HK-II at Th ...... ion to protect cardiomyocytes.

@nl

prefLabel

Akt phosphorylates HK-II at Th ...... tion to protect cardiomyocytes

@en

Akt phosphorylates HK-II at Th ...... ion to protect cardiomyocytes.

@nl

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JBC.M113.482026

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Journal of Biological Chemistry

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Akt phosphorylates HK-II at Th ...... tion to protect cardiomyocytes

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David J Roberts

http://www.w3.org/2001/XMLSchema#string

Jeffery M Smith

http://www.w3.org/2001/XMLSchema#string

Shigeki Miyamoto

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Valerie P Tan-Sah

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P2860

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

The cardiac mitochondrion: nexus of stress

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Bax regulates primary necrosis through mitochondrial dynamics

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

Control of glucose utilization in working perfused rat heart

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23798-23806

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scholarly article

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10.1074/JBC.M113.482026

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33

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288

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2013-07-08T00:00:00Z

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23836898

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phosphorylation

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3745326

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