Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.
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H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activityOxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsReactive oxygen species in inflammation and tissue injuryMeasurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysisPeroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge.Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice.Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication.Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review.Of mice and men: comparative proteomics of bronchoalveolar fluid.Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury.Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivoPulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment.Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis.Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onsetMultiple roles of phospholipase A2 during lung infection and inflammation.A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung.Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies.Peptide targeting and imaging of damaged lung tissue in influenza-infected micePeroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress.CFTR activity and mitochondrial function.Environmental toxicity, redox signaling and lung inflammation: the role of glutathioneContributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects.Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.Adiponectin protects against hyperoxic lung injury and vascular leakCurrent perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease.Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A₂ activities.Novel roles of peroxiredoxins in inflammation, cancer and innate immunity.Phospholipase A(2) of peroxiredoxin 6 has a critical role in tumor necrosis factor-induced apoptosis.Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.Differential expression and function of peroxiredoxin 1 and peroxiredoxin 6 in cancerous MCF-7 and noncancerous MCF-10A breast epithelial cells.Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis.
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Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 January 2006
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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P2093
P2860
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P1476
Transgenic mice overexpressing ...... e to lung injury in hyperoxia.
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Aron B Fisher
Sheldon I Feinstein
Shelley A Phelan
Yefim Manevich
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P304
P356
10.1165/RCMB.2005-0333OC
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2006-01-06T00:00:00Z