Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.
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Cancer stem cells and signaling pathways in radioresistanceTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyExpression-based in silico screening of candidate therapeutic compounds for lung adenocarcinomaSildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway.Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1αRAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal responseA first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies.Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1-mediated transcriptional eventsThe anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1αRadiation, inflammation, and immune responses in cancerModulation of Wnt/β-catenin signaling pathway by bioactive food components.Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.The "Sharp" blade against HIF-mediated metastasis.Cancer and diet: How are they related?A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression.Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization.Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells.Targeting the hypoxia-inducible factor (HIF) pathway in cancer.Ηypoxia-inducible factor-1α, von Hippel-Lindau protein, and heat shock protein expression in ophthalmic pterygium and normal conjunctiva.Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma.Cancer stem cells: a new framework for the design of tumor therapies.HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.Targeting tumour angiogenesis with small molecule inhibitors of hypoxia inducible factor.The heat shock proteins as targets for radiosensitization and chemosensitization in cancerHypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases.HSP90AB1: Helping the good and the bad.Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibitionExamination of Gossypol-Pluronic Micelles as Potential Radiosensitizers.Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis.Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.(-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α.Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.Basal HIF-1α expression levels are not predictive for radiosensitivity of human cancer cell lines.Radiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies.
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Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@en
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@nl
type
label
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@en
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@nl
prefLabel
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@en
Targeting heat shock protein 9 ...... poxia-inducible factor-1alpha.
@nl
P2093
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P1476
Targeting heat shock protein 9 ...... ypoxia-inducible factor-1alpha
@en
P2093
Ho-Young Lee
Seung Hyun Oh
Waun Ki Hong
Woo-Young Kim
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P304
P356
10.1158/0008-5472.CAN-08-0505
P407
P50
P577
2009-01-27T00:00:00Z