Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

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Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.

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Q35964756-57DDC56C-887E-46F1-9B87-811C216A51FD

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Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

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http://www.wikidata.org/entity/Q37108906

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 07 December 2015

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities

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Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities.

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Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities

@en

Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities.

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Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities

@en

Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities.

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P1476

Novel Microtubule-Targeting 7- ...... in Vivo Anticancer Activities

@en

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Alexander Kornienko

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Charles B Shuster

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Daniel V LaBarbera

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Derek C Medellin

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Ernest Hamel

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Liliya V Frolova

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Qiong Zhou

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R Matthew Hill

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Ramesh Dasari

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Robert Scott

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Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins

Structural plasticity of tubulin assembly probed by vinca-domain ligands

Trabectedin in soft tissue sarcomas

One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.

Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.

Marine natural products as anticancer drugs.

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.

Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

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480-485

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scholarly article

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10.1021/ACS.JMEDCHEM.5B01426

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English

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P478

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Tania Betancourt

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2015-12-07T00:00:00Z

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286220070

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26641132

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4950951

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Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

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P2860

P2860

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

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prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

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P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

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P698

P932