Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects
about
Head and neck cancer: metronomic chemotherapySequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer.Personalizing Medicine in Head and Neck Squamous Cell Carcinoma: The Rationale for Combination Therapies(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice.Modeling head and neck cancer stem cell-mediated tumorigenesis.Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotypeLovastatin-induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal.Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells.Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.
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P2860
Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 08 December 2011
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Metronomic dosing of BH3 mimet ...... giogenic and antitumor effects
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Metronomic dosing of BH3 mimet ...... iogenic and antitumor effects.
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type
label
Metronomic dosing of BH3 mimet ...... giogenic and antitumor effects
@en
Metronomic dosing of BH3 mimet ...... iogenic and antitumor effects.
@nl
prefLabel
Metronomic dosing of BH3 mimet ...... giogenic and antitumor effects
@en
Metronomic dosing of BH3 mimet ...... iogenic and antitumor effects.
@nl
P2093
P2860
P1433
P1476
Metronomic dosing of BH3 mimet ...... giogenic and antitumor effects
@en
P2093
Atsushi Imai
Emily Light
Fernanda Visioli
Frank Worden
Jacques E Nör
Sudha Krishnamurthy
Zhaocheng Zhang
Zhihong Dong
P2860
P304
P356
10.1158/0008-5472.CAN-10-2873
P407
P577
2011-12-08T00:00:00Z