Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
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PP2A delays APC/C-dependent degradation of separase-associated but not free securinProtein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.Overexpression of a truncated CTF7 construct leads to pleiotropic defects in reproduction and vegetative growth in Arabidopsis.Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.The sister bonding of duplicated chromosomes.Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.DNA-dependent cohesin cleavage by separase.Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.
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Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Preimplantation mouse embryos ...... vent chromosome missegregation
@en
Preimplantation mouse embryos ...... ent chromosome missegregation.
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type
label
Preimplantation mouse embryos ...... vent chromosome missegregation
@en
Preimplantation mouse embryos ...... ent chromosome missegregation.
@nl
prefLabel
Preimplantation mouse embryos ...... vent chromosome missegregation
@en
Preimplantation mouse embryos ...... ent chromosome missegregation.
@nl
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Preimplantation mouse embryos ...... vent chromosome missegregation
@en
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Austin J Cooney
Claudia V Andreu-Vieyra
Martin M Matzuk
Meizhi Wang
Pumin Zhang
Xingxu Huang
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10.1128/MCB.01778-08
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P577
2009-01-05T00:00:00Z