The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer
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Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast CancerAutophagy in cellular metabolism and cancerAutophagy in cancerChloroquine-enhanced efficacy of cisplatin in the treatment of hypopharyngeal carcinoma in xenograft miceCo-Targeting of JNK and HUNK in Resistant HER2-Positive Breast CancerSTAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.Autophagy inhibition impairs the epithelial-mesenchymal transition and enhances cisplatin sensitivity in nasopharyngeal carcinoma.Current Approaches and Emerging Directions in HER2-resistant Breast Cancer.Targeting autophagy in breast cancer.Tumour cell invasion: an emerging role for basal epithelial cell extrusion.Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumorsExon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.Knockdown of heme oxygenase-1 promotes apoptosis and autophagy and enhances the cytotoxicity of doxorubicin in breast cancer cells.Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancersChloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment.Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitroATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation.Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis.A Quinacrine Analogue Selective Against Gastric Cancer Cells: Insight from Biochemical and Biophysical Studies.Overexpression of microRNA-96-5p inhibits autophagy and apoptosis and enhances the proliferation, migration and invasiveness of human breast cancer cells.The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to γ-rays and/or erlotinib.Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.EGFR Family Members' Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer.Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile.Low concentration of chloroquine enhanced efficacy of cisplatin in the treatment of human ovarian cancer dependent on autophagyInhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress.A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery.Targeting protein quality control pathways in breast cancer.Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells.Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents.Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking.The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway.CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species.Autophagy flux inhibition augments gastric cancer resistance to the anti-human epidermal growth factor receptor 2 antibody trastuzumab.
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P2860
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
The anti-malarial chloroquine ...... in HER2-positive breast cancer
@en
The anti-malarial chloroquine ...... n HER2-positive breast cancer.
@nl
type
label
The anti-malarial chloroquine ...... in HER2-positive breast cancer
@en
The anti-malarial chloroquine ...... n HER2-positive breast cancer.
@nl
prefLabel
The anti-malarial chloroquine ...... in HER2-positive breast cancer
@en
The anti-malarial chloroquine ...... n HER2-positive breast cancer.
@nl
P2093
P2860
P50
P356
P1433
P1476
The anti-malarial chloroquine ...... in HER2-positive breast cancer
@en
P2093
Alejandro Vazquez-Martin
Bruna Corominas-Faja
Cristina Oliveras-Ferraros
Eugeni López-Bonet
Sílvia Cufí
P2860
P2888
P356
10.1038/SREP02469
P407
P577
2013-01-01T00:00:00Z