Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
about
Regulation and roles of Ca2+ stores in human spermSLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertilityStructurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor.SLO3 K+ channels control calcium entry through CATSPER channels in sperm.The CatSper channel controls chemosensation in sea urchin spermMechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and bariumCRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization.Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.A K(+)-selective CNG channel orchestrates Ca(2+) signalling in zebrafish sperm.Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization.The Ca2+-activated K+ current of human sperm is mediated by Slo3.Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels.T-type Ca2+ channels in spermatogenic cells and sperm.Role of Ion Channels in the Sperm Acrosome Reaction.Sperm Capacitation and Acrosome Reaction in Mammalian Sperm.Sperm Sensory Signaling.International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF.
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Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Simultaneous knockout of Slo3 ...... d current in mouse spermatozoa
@en
Simultaneous knockout of Slo3 ...... current in mouse spermatozoa.
@nl
type
label
Simultaneous knockout of Slo3 ...... d current in mouse spermatozoa
@en
Simultaneous knockout of Slo3 ...... current in mouse spermatozoa.
@nl
prefLabel
Simultaneous knockout of Slo3 ...... d current in mouse spermatozoa
@en
Simultaneous knockout of Slo3 ...... current in mouse spermatozoa.
@nl
P2093
P2860
P356
P1476
Simultaneous knockout of Slo3 ...... d current in mouse spermatozoa
@en
P2093
Betsy Navarro
Xiao-Ming Xia
Xu-Hui Zeng
P2860
P304
P356
10.1085/JGP.201311011
P577
2013-09-01T00:00:00Z