Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists
about
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyMolecular recognition at purine and pyrimidine nucleotide (P2) receptors.MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in miceDevelopment of selective agonists and antagonists of P2Y receptors.Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory painStroke neuroprotection: targeting mitochondriaPharmacochemistry of the platelet purinergic receptors.Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors.Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic musclesThe E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.Molecular recognition at adenine nucleotide (P2) receptors in platelets.Northern Ring Conformation of Methanocarba-Adenosine 5'-Triphosphate Required for Activation of P2X Receptors.Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activityAction of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressureDevelopment of a comprehensive set of P2 receptor pharmacological research compoundsP2Y(1) receptors mediate inhibitory neuromuscular transmission in the rat colon.Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells.Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses.Synthesis of ethyl (1S,2R,3S,4S,5S)-2,3-O-(isopropylidene)-4-hydroxy-bicyclo[3.1.0]hexane-carboxylate from L-ribose: a versatile chiral synthon for preparation of adenosine and P2 receptor ligands.Pharmacological characterization of purinergic inhibitory neuromuscular transmission in the human colon.Polypharmacology of conformationally locked methanocarba nucleosides.
P2860
Q24629255-C56212D3-412A-46CF-A9DD-128718EFA4BDQ33201399-F68ED4B6-0D6A-404A-898B-3B31B62F2BC8Q33225547-CDBB6EF1-3F30-42ED-AFC6-CB385C65E9E7Q33348980-7DB6B823-C63B-4A85-9875-D869F92A61F5Q33584104-23088916-3B2F-40EB-904E-5E7E18B86822Q33730614-67FEA197-236E-4504-82B9-7414843EAFBCQ33772138-5E77EA18-F6A9-490D-9351-D416BB332435Q33869922-7F3AE379-2E80-495D-B630-0117D47DDF5BQ33890891-5AB85524-282D-450E-A2EF-CE62046163A4Q33894544-29D02173-EDD3-482B-AF8E-A2556DBD0B44Q34201039-5BB80DD6-7D0E-40CC-ADD6-7AD2C6C823C7Q34769236-F4BE947C-0B94-44DE-A9D9-3DFE5DF746E0Q35050462-EAF13B7A-53AC-42BD-8116-FA10C867A1A9Q35163180-761CF8E8-E4A6-47A8-BB30-B372C3C10044Q35177000-BFBA7617-F3E6-4AC9-895D-40ED630E860CQ35580443-793C4564-8539-475D-A88C-284657F1151AQ36108563-BDD1E066-813D-4147-9C9E-1B4CC5F4F588Q36110665-C096B6AA-D16B-4EE4-990C-6CC32AA6203DQ36147741-E8EFED79-78AD-4560-A140-1E0E041628CEQ36282943-0C156014-9550-403C-95B3-C7615FBBC37DQ36614939-AC3EABBA-9754-4EC3-9A84-8E3EE273EF16Q36635966-6012B3BC-0286-4D27-A9AA-D9FA5B2B75B3Q36790061-B888BB7D-6004-4376-B419-06377A43C115Q37341915-3450EE4F-E76A-4006-A751-4BBA302CEEB7Q39722931-5BD92CC5-B7C5-44B7-B873-4FF3E6BA9306Q40643618-C004BB58-27A0-469B-B953-F89D2E3EB23EQ42951349-576D967E-5EF3-4EF1-93B7-D6A3924295B2Q44212098-8C86A07E-700D-482A-8E85-165195E96D9EQ46252915-2FC44DB8-C3FE-4690-AB27-59C84E10FA29Q46764720-47219D7E-21F7-4C2C-8339-A795C3181A05Q50536330-5F1C4BA6-D810-45D8-AF33-5984E9B63F55Q53123581-7FD762B5-6E46-4B59-A6EC-A2C82EF286A1
P2860
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2002
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Adenine nucleotide analogues l ...... d stability and potency as P2Y
@nl
Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists
@en
type
label
Adenine nucleotide analogues l ...... d stability and potency as P2Y
@nl
Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists
@en
prefLabel
Adenine nucleotide analogues l ...... d stability and potency as P2Y
@nl
Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists
@en
P2093
P2860
P356
P1476
Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists
@en
P2093
Hak Sung Kim
Herbert Zimmermann
José L Boyer
Jörg Servos
Kyeong Lee
R Gnana Ravi
Savitri Maddileti
T Kendall Harden
P2860
P304
P356
10.1021/JM010538V
P407
P577
2002-05-01T00:00:00Z