Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists - Wikidata - wikimedia - TriplyDB

Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists

Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists

http://www.wikidata.org/entity/Q37122033

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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice Development of selective agonists and antagonists of P2Y receptors.Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain Stroke neuroprotection: targeting mitochondria Pharmacochemistry of the platelet purinergic receptors.Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors.Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.Molecular recognition at adenine nucleotide (P2) receptors in platelets.Northern Ring Conformation of Methanocarba-Adenosine 5'-Triphosphate Required for Activation of P2X Receptors.Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure Development of a comprehensive set of P2 receptor pharmacological research compounds P2Y(1) receptors mediate inhibitory neuromuscular transmission in the rat colon.Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells.Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses.Synthesis of ethyl (1S,2R,3S,4S,5S)-2,3-O-(isopropylidene)-4-hydroxy-bicyclo[3.1.0]hexane-carboxylate from L-ribose: a versatile chiral synthon for preparation of adenosine and P2 receptor ligands.Pharmacological characterization of purinergic inhibitory neuromuscular transmission in the human colon.Polypharmacology of conformationally locked methanocarba nucleosides.

P2860

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P2860

Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists

http://www.wikidata.org/entity/Q37122033

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2002

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Adenine nucleotide analogues l ...... d stability and potency as P2Y

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Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists

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Adenine nucleotide analogues l ...... d stability and potency as P2Y

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Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists

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Adenine nucleotide analogues l ...... d stability and potency as P2Y

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Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists

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Journal of Medicinal Chemistry

P1476

Adenine nucleotide analogues l ...... cy as P2Y(1) receptor agonists

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P2093

Hak Sung Kim

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Herbert Zimmermann

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José L Boyer

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Jörg Servos

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Kyeong Lee

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R Gnana Ravi

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Savitri Maddileti

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T Kendall Harden

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P2860

A G protein-coupled receptor for UDP-glucose

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999

Identification of the platelet ADP receptor targeted by antithrombotic drugs

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Heteromeric association creates a P2Y-like adenosine receptor

Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides

Identification of a novel human ADP receptor coupled to G(i)

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications

The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor

P304

2090-2100

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scholarly article

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10.1021/JM010538V

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P407

P433

10

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P478

45

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Kenneth A. Jacobson

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2002-05-01T00:00:00Z

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11985476

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4959107

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