Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection.
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Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the hostDevelopment, characterization and application of monoclonal antibodies against Brazilian Dengue virus isolatesVirus-like particles derived from Pichia pastoris-expressed dengue virus type 1 glycoprotein elicit homotypic virus-neutralizing envelope domain III-directed antibodiesStructure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant EpitopeA high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopesDengue E Protein Domain III-Based DNA Immunisation Induces Strong Antibody Responses to All Four Viral SerotypesDeconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and ImmunityMapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to DENV4 Infection and VaccinationCharacterization of Zika virus binding and enhancement potential of a large panel of flavivirus murine monoclonal antibodies.Recombinant Dengue Virus 4 Envelope Glycoprotein Virus-Like Particles Derived from Pichia pastoris are Capable of Eliciting Homotypic Domain III-Directed Neutralizing Antibodies.A Dengue Virus Type 4 Model of Disseminated Lethal Infection in AG129 MiceDefining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection.Virus-like particle secretion and genotype-dependent immunogenicity of dengue virus serotype 2 DNA vaccineThe potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope proteinTemperature dependent conformational change of dengue virusCharacterization of a Novel Dengue Serotype 4 Virus-Specific Neutralizing Epitope on the Envelope Protein Domain III.A new quaternary structure epitope on dengue virus serotype 2 is the target of durable type-specific neutralizing antibodies.Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing.Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-α/β and IFN-γ receptors (AG129) and comparison with the DENV-2 AG129 mouse model.A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection.B cell response and mechanisms of antibody protection to West Nile virus.DNA-immunisation with dengue virus E protein domains I/II, but not domain III, enhances Zika, West Nile and Yellow Fever virus infection.Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.HCV E2 core structures and mAbs: something is still missing.Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development.Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development.A mouse monoclonal antibody against dengue virus type 1 Mochizuki strain targeting envelope protein domain II and displaying strongly neutralizing but not enhancing activity.Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials.Pichia pastoris-expressed dengue 3 envelope-based virus-like particles elicit predominantly domain III-focused high titer neutralizing antibodies.Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection.A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo.Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.Dengue envelope-based 'four-in-one' virus-like particles produced using Pichia pastoris induce enhancement-lacking, domain III-directed tetravalent neutralising antibodies in mice.
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Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 June 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Functional analysis of antibod ...... neutralization and protection.
@en
Functional analysis of antibod ...... neutralization and protection.
@nl
type
label
Functional analysis of antibod ...... neutralization and protection.
@en
Functional analysis of antibod ...... neutralization and protection.
@nl
prefLabel
Functional analysis of antibod ...... neutralization and protection.
@en
Functional analysis of antibod ...... neutralization and protection.
@nl
P2093
P2860
P50
P356
P1433
P1476
Functional analysis of antibod ...... neutralization and protection.
@en
P2093
Benjamin J Doranz
Daved H Fremont
James D Brien
Kristen Kahle
S Kyle Austin
Sherri Swayne
Syd Johnson
P2860
P304
P356
10.1128/JVI.01314-13
P407
P577
2013-06-19T00:00:00Z