Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism
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Human conditions of insulin-like growth factor-I (IGF-I) deficiencyA novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate.Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with RosiglitazoneInsulin-like growth factor 1 physiology: lessons from mouse models.Caloric restriction leads to high marrow adiposity and low bone mass in growing miceDirect stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- miceIGF-I regulates the age-dependent signaling peptide humanin.Anorexia nervosa: a unified neurological perspectiveEvidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner.Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo.Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).Why does starvation make bones fat?IGF-1 and bone: New discoveries from mouse modelsUnbound (bioavailable) IGF1 enhances somatic growth.Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis.The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes MellitusMaternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene.The role of IGF-1 for fracture risk in men.Genetic regulation of the growth plateDMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments.Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions.Low levels of plasma IGF-1 inhibit intracortical bone remodeling during agingThe acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolismSerum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.The role of liver-derived insulin-like growth factor-I.Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.Insulin-like growth factor binding protein-3 links obesity and breast cancer progression.Role of insulin-like growth factor-1 in the regulation of skeletal growth.Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism.Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement.Humanin: Functional Interfaces with IGF-I.Skeletal effects of growth hormone and insulin-like growth factor-I therapy.Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.Bone Status in a Patient with Insulin-Like Growth Factor-1 Receptor Deletion Syndrome: Bone Quality and Structure Evaluation Using Dual-Energy X-Ray Absorptiometry, Peripheral Quantitative Computed Tomography, and Quantitative Ultrasonography.Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice.
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Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 24 October 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Serum complexes of insulin-lik ...... ty and carbohydrate metabolism
@en
Serum complexes of insulin-lik ...... y and carbohydrate metabolism.
@nl
type
label
Serum complexes of insulin-lik ...... ty and carbohydrate metabolism
@en
Serum complexes of insulin-lik ...... y and carbohydrate metabolism.
@nl
prefLabel
Serum complexes of insulin-lik ...... ty and carbohydrate metabolism
@en
Serum complexes of insulin-lik ...... y and carbohydrate metabolism.
@nl
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P2860
P356
P1433
P1476
Serum complexes of insulin-lik ...... ty and carbohydrate metabolism
@en
P2093
Clifford J Rosen
David Clemmons
David Hwang
Horacio Domene
Héctor Jasper
Jan Frystyk
John Pintar
Karl Jepsen
Kelly Emerton
P2860
P304
P356
10.1096/FJ.08-118976
P407
P577
2008-10-24T00:00:00Z