Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.
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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoproteinA Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor SuppressorsAdenovirus Early Proteins and Host SumoylationThe adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note.The N terminus of adenovirus type 12 E1A inhibits major histocompatibility complex class I expression by preventing phosphorylation of NF-kappaB p65 Ser276 through direct binding.Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis.Modulation of allostery by protein intrinsic disorder.Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection.Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation.A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication.Opposing oncogenic activities of small DNA tumor virus transforming proteins.Intrinsically disordered proteins in cellular signalling and regulation.Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.T-cell subsets in peripheral blood and tumors of patients treated with oncolytic adenoviruses.Transformation by E1A oncoprotein involves ubiquitin-mediated proteolysis of the neuronal and tumor repressor REST in the nucleus.Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral OncoproteinRole of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A.Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Down-regulation of multiple cell survival proteins in head and neck cancer cells by an apoptogenic mutant of adenovirus type 5.Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis.Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis.Oncolytic (replication-competent) adenoviruses as anticancer agents.The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.An unhealthy relationship: viral manipulation of the nuclear receptor superfamily.The C-terminal region of E1A: a molecular tool for cellular cartography.Adenovirus degradation of cellular proteins.The anti-tumor activity of E1A and its implications in cancer therapy.Adenovirus E1A directly targets the E2F/DP-1 complex.The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin.Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain.The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16.The Dual Nature of Nek9 in Adenovirus Replication.Effects of Adenovirus Type 5 E1A Isoforms on Viral Replication in Arrested Human CellsPromyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression.
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Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Intrinsic structural disorder ...... ng multiple diverse processes.
@en
Intrinsic structural disorder ...... ng multiple diverse processes.
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type
label
Intrinsic structural disorder ...... ng multiple diverse processes.
@en
Intrinsic structural disorder ...... ng multiple diverse processes.
@nl
prefLabel
Intrinsic structural disorder ...... ng multiple diverse processes.
@en
Intrinsic structural disorder ...... ng multiple diverse processes.
@nl
P2093
P2860
P356
P1433
P1476
Intrinsic structural disorder ...... ing multiple diverse processes
@en
P2093
Gregory J Fonseca
Jailal N G Ablack
Joe S Mymryk
Peter Pelka
P2860
P304
P356
10.1128/JVI.00104-08
P407
P577
2008-04-02T00:00:00Z