The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.
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Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID FamiliesReplication-Associated Recombinational Repair: Lessons from Budding YeastCooperativity of the SUMO and Ubiquitin Pathways in Genome StabilityLinking replication stress with heterochromatin formationMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeDNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent ComplexesInterplay between the Smc5/6 complex and the Mph1 helicase in recombinational repairSumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencingPolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangementsGenetic instability in budding and fission yeast-sources and mechanismsCharacterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stressSaccharomyces cerevisiae Esc2p interacts with Sir2p through a small ubiquitin-like modifier (SUMO)-binding motif and regulates transcriptionally silent chromatin in a locus-dependent manner.Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switchThe Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiaeThe Smc5-Smc6 complex is required to remove chromosome junctions in meiosis.Visualization of recombination-mediated damage bypass by template switching.The Smc5-Smc6 complex regulates recombination at centromeric regions and affects kinetochore protein sumoylation during normal growth.Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex.The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.Restriction of replication fork regression activities by a conserved SMC complex.Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.Roles of vertebrate Smc5 in sister chromatid cohesion and homologous recombinational repair.Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance.The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.Selective modulation of the functions of a conserved DNA motor by a histone fold complex.Heterochromatin formation via recruitment of DNA repair proteins.Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplexChromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains.Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutantsA saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability
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The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
@en
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
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type
label
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
@en
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
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prefLabel
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
@en
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
@nl
P2093
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P50
P356
P1476
The Saccharomyces cerevisiae E ...... ction-mediated intra-S repair.
@en
P2093
Federica Castellucci
Julie Sollier
Robert Driscoll
P2860
P304
P356
10.1091/MBC.E08-08-0875
P577
2009-01-21T00:00:00Z