An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.
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The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to IntegrationSUMO-interacting motifs of human TRIM5α are important for antiviral activityRestriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Trafficking of some old world primate TRIM5α proteins through the nucleus.Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomersEvolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid InterfaceTRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6Stonefish toxin defines an ancient branch of the perforin-like superfamily.Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5α-mediated restriction.Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.Human cellular restriction factors that target HIV-1 replication.The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors.Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape.Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses
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P2860
An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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An invariant surface patch on ...... ispensable for capsid binding.
@en
An invariant surface patch on ...... ispensable for capsid binding.
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type
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An invariant surface patch on ...... ispensable for capsid binding.
@en
An invariant surface patch on ...... ispensable for capsid binding.
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An invariant surface patch on ...... ispensable for capsid binding.
@en
An invariant surface patch on ...... ispensable for capsid binding.
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P2093
P2860
P50
P356
P1433
P1476
An invariant surface patch on ...... ispensable for capsid binding.
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P2093
Christian Grütter
Markus G Grütter
Sarah Sebastian
Silvia Olivari
P2860
P304
P356
10.1128/JVI.00432-08
P407
P577
2009-01-19T00:00:00Z