Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase.
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HIVToolbox, an integrated web application for investigating HIVHIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchCrystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteRetroviral Integrase: Then and NowResistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitorsBiochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection.Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.Altered viral fitness and drug susceptibility in HIV-1 carrying mutations that confer resistance to nonnucleoside reverse transcriptase and integrase strand transfer inhibitors.Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development.Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants.Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus.Retroviral DNA Transposition: Themes and VariationsReverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.Human immunodeficiency virus type 1 employs the cellular dynein light chain 1 protein for reverse transcription through interaction with its integrase proteinThe removal of RNA primers from DNA synthesized by the reverse transcriptase of the retrotransposon Tf1 is stimulated by Tf1 integraseRole of host-encoded proteins in restriction of retroviral integration.Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Novel integrase inhibitors for HIV.Next-generation integrase inhibitors : where to after raltegravir?Bridging the past and the future of virology: surface plasmon resonance as a powerful tool to investigate virus/host interactions.A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cellsInhibiting the HIV integration process: past, present, and the future.Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir.Comparison of the thermal stabilities of the αβ heterodimer and the α subunit of avian myeloblastosis virus reverse transcriptase.Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1.Coevolutionary Analysis Identifies Protein-Protein Interaction Sites between HIV-1 Reverse Transcriptase and IntegraseIdentification of interaction between HIV-1 glycoprotein 41 and integrase.Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes.HIV-1 B-subtype capsid protein: a characterization of amino acid's conservation and its significant association with integrase signatures.Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors.Biochemical interactions between HIV-1 integrase and reverse transcriptase.
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P2860
Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identifying and characterizing ...... ase-binding site on integrase.
@en
Identifying and characterizing ...... ase-binding site on integrase.
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type
label
Identifying and characterizing ...... ase-binding site on integrase.
@en
Identifying and characterizing ...... ase-binding site on integrase.
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Identifying and characterizing ...... ase-binding site on integrase.
@en
Identifying and characterizing ...... ase-binding site on integrase.
@nl
P2093
P2860
P356
P1476
Identifying and characterizing ...... ase-binding site on integrase.
@en
P2093
Jennifer T Miller
Kurt Januszyk
Martin L Phillips
Robert T Clubb
Samson A Chow
Shewit S Tekeste
Stuart F J Le Grice
Thomas A Wilkinson
P2860
P304
P356
10.1074/JBC.M806241200
P407
P577
2009-01-16T00:00:00Z