Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. - Wikidata - wikimedia - TriplyDB

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.

http://www.wikidata.org/entity/Q37142178

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High accuracy mutation detection in leukemia on a selected panel of cancer genes NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3 The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study.Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma Janus kinase 3: the controller and the controlled Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.Pharmacological control of receptor of advanced glycation end-products and its biological effects in psoriasis.JAK3: a two-faced player in hematological disorders Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.Disease-specific mutations in mature lymphoid neoplasms: recent advances.Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma.JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1.Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors.Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia.A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling.Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma.Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.

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Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.

http://www.wikidata.org/entity/Q37142178

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 12 January 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Constitutive JAK3 activation i ...... marrow transplantation models.

@en

Constitutive JAK3 activation i ...... marrow transplantation models.

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type

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Constitutive JAK3 activation i ...... marrow transplantation models.

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Constitutive JAK3 activation i ...... marrow transplantation models.

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prefLabel

Constitutive JAK3 activation i ...... marrow transplantation models.

@en

Constitutive JAK3 activation i ...... marrow transplantation models.

@nl

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BLOOD-2008-06-164368

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Constitutive JAK3 activation i ...... marrow transplantation models.

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Benjamin H Lee

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Brian Ball

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D Gary Gilliland

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Harvey Cantor

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Jean-Philippe Merlio

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Jon C Aster

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Melanie G Cornejo

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Michael G Kharas

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Miriam B Werneck

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Sandra A Moore

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P2860

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.

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2746-2754

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scholarly article

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10.1182/BLOOD-2008-06-164368

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12

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Marie Beylot-Barry

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2009-01-12T00:00:00Z

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19139084

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