Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice.
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Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in miceRole of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function.The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursorsPromising bone-related therapeutic targets for rheumatoid arthritis.The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts.RANK receptor oligomerisation in the regulation of NFκB signalling.Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.Osteoclast motility: putting the brakes on bone resorption.Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis.PKCβ positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3β.The orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation.Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function.Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis.Osteoclasts: New InsightsMolecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis.The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis.Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice.Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesisThe role of T cells in osteoporosis, an update.Immunology and bone.Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts.The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy.Geraniin inhibits TNF-α-induced impairments of osteogenesis through NF-κB and p38 MAPK signalling pathways in bone marrow stem cells.GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock.Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation.C/EBPα is Regulated by the RANK Cytoplasmic IVVY535-538 Motif and Stimulates Osteoclastogenesis more Strongly than c-Fos.Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-κB and Its Ligand.STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex.Supramolecular assemblies of histidinylated β-cyclodextrin for enhanced oligopeptide delivery into osteoclast precursors.Water extract of Magnolia officinalis cortex inhibits osteoclastogenesis and bone resorption by downregulation of nuclear factor of activated T cells cytoplasmic 1.A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss.PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized miceThe purinergic receptor P2X5 contributes to bone loss in experimental periodontitis
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Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 02 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@en
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@nl
type
label
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@en
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@nl
prefLabel
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@en
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@nl
P2093
P2860
P356
P1476
Selective inhibition of RANK b ...... nd prevents bone loss in mice.
@en
P2093
Chang-Yong Ko
Daewon Jeong
Han Kyoung Choi
Han-Sung Kim
Hong-In Shin
Hwa Jeong Lee
Hyunsoo Kim
Ji Hye Shin
Ji Young Huh
Kyung Hee Kim
P2860
P304
P356
10.1172/JCI36809
P407
P577
2009-03-02T00:00:00Z