Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. - Wikidata - wikimedia - TriplyDB

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice.

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice.

http://www.wikidata.org/entity/Q37143375

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Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function.The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors Promising bone-related therapeutic targets for rheumatoid arthritis.The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts.RANK receptor oligomerisation in the regulation of NFκB signalling.Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.Osteoclast motility: putting the brakes on bone resorption.Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis.PKCβ positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3β.The orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation.Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function.Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis.Osteoclasts: New Insights Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis.The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis.Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice.Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis The role of T cells in osteoporosis, an update.Immunology and bone.Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts.The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy.Geraniin inhibits TNF-α-induced impairments of osteogenesis through NF-κB and p38 MAPK signalling pathways in bone marrow stem cells.GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock.Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation.C/EBPα is Regulated by the RANK Cytoplasmic IVVY535-538 Motif and Stimulates Osteoclastogenesis more Strongly than c-Fos.Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-κB and Its Ligand.STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex.Supramolecular assemblies of histidinylated β-cyclodextrin for enhanced oligopeptide delivery into osteoclast precursors.Water extract of Magnolia officinalis cortex inhibits osteoclastogenesis and bone resorption by downregulation of nuclear factor of activated T cells cytoplasmic 1.A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss.PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis

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P2860

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice.

http://www.wikidata.org/entity/Q37143375

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 02 March 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@en

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@nl

type

label

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@en

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@nl

prefLabel

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@en

Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@nl

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Journal of Clinical Investigation

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Selective inhibition of RANK b ...... nd prevents bone loss in mice.

@en

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Chang-Yong Ko

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Daewon Jeong

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Han Kyoung Choi

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Han-Sung Kim

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Hong-In Shin

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Hwa Jeong Lee

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Hyunsoo Kim

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Ji Hye Shin

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Ji Young Huh

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Kyung Hee Kim

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P2860

Biology of RANK, RANKL, and osteoprotegerin

Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

RANK-L and RANK: T cells, bone loss, and mammalian evolution

Skeletal remodeling in health and disease

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Osteoimmunology: interplay between the immune system and bone metabolism

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813-825

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scholarly article

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10.1172/JCI36809

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P407

P433

4

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119

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2009-03-02T00:00:00Z

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19258703

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2662555

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