Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation.
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A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αThe Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle FunctionA novel structural mechanism for redox regulation of uridine phosphorylase 2 activityROS homeostasis and metabolism: a critical liaison for cancer therapySpatiotemporal regulation of Src and its substrates at invadosomesBiological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol ModificationsIntrinsic Photosensitivity Enhances Motility of T Lymphocytes.Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseasesATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17.Redox signaling and cardiac sarcomeresMechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cellsModulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes.Cysteine-mediated redox signaling: chemistry, biology, and tools for discoveryRedox regulation of protein kinases.Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation.Redox signaling at invasive microdomains in cancer cells.Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish.The role of Src kinase in macrophage-mediated inflammatory responses.Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation.Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity.Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons.Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies.Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.Redox regulation of Janus kinase: The elephant in the room.Orchestrating redox signaling networks through regulatory cysteine switches.The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies.S-glutathiolation in life and death decisions of the cell.Mitochondrial superoxide dismutase--signals of distinction.ROS signaling and redox biology in endothelial cells.Systematic and quantitative assessment of hydrogen peroxide reactivity with cysteines across human proteomes.4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B.TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism.Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species.Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation.S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion.Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions.The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.
P2860
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P2860
Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Direct and specific inactivati ...... reversible cysteine oxidation.
@en
Direct and specific inactivati ...... reversible cysteine oxidation.
@nl
type
label
Direct and specific inactivati ...... reversible cysteine oxidation.
@en
Direct and specific inactivati ...... reversible cysteine oxidation.
@nl
prefLabel
Direct and specific inactivati ...... reversible cysteine oxidation.
@en
Direct and specific inactivati ...... reversible cysteine oxidation.
@nl
P2860
P356
P1476
Direct and specific inactivati ...... reversible cysteine oxidation.
@en
P2093
David J Kemble
Gongqin Sun
P2860
P304
P356
10.1073/PNAS.0806117106
P407
P577
2009-03-09T00:00:00Z