Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice. - Wikidata - wikimedia - TriplyDB

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

http://www.wikidata.org/entity/Q37151181

about

RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1 New Financial and Research Models for Pediatric Orphan Drug Development - Focus on the NCATS TRND Program CBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes Mapping of MN1 sequences necessary for myeloid transformation.Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche Inducible expression of Runx2 results in multiorgan abnormalities in mice.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.Gfi1-cells and circuits: unraveling transcriptional networks of development and disease The RUNX family in breast cancer: relationships with estrogen signaling.RUNX2 in mammary gland development and breast cancer.EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia.Mouse models for core binding factor leukemia.Genetic regulation of the RUNX transcription factor family has antitumor effects Transcriptional regulation by RUNX2 The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.

P2860

Q26800112-373F598B-2293-46AC-8087-4F51C24B2652 Q30252938-733DD91F-0B54-4364-92CD-9DAF7D05D190 Q30432285-62A5EB8D-A60F-48BE-8E3E-974D005164EE Q33621814-5A106941-1A82-4D45-88E3-6C1AD849200B Q34353095-ABC55DB2-E816-44DA-993D-B76E2808121F Q34692292-0AB599B3-F4B0-44E8-8CE5-720015568C39 Q35081686-649F075B-896E-40FC-A916-6079C0ED3FAF Q35105746-95B17CCF-1D7B-432F-AD8D-309D9B17FCEF Q36259601-BA9AB3B6-3155-42DC-BF66-7160984F9FBD Q36309953-7CEB5165-46CE-4D50-BAF8-9E1DC88968DE Q36395604-DDFFB4F4-433B-4F07-AB6A-2E04E4DE8430 Q36827373-D5C5063F-A767-46FC-A2DD-E61EB62740FD Q36915154-EE673BBE-F1A4-4633-822A-F40E1A23792C Q37365273-EAEA5BCE-3099-433D-8AA9-F0DD3F525849 Q37662400-CADF580D-2FC7-4F0B-AADA-3DAF8D2D8D77 Q37687744-47FB469F-E7A3-4576-93C9-7DE4C8039EEC Q37767120-2E8BBFC0-17C2-417F-89CC-F4752F308916 Q38050410-2A72994E-735D-45B9-97D4-EF593FDB4460 Q38061373-C08B9F43-8BCE-415B-B8F6-47EFE6C6ED75 Q38345216-39B5D630-A83F-45C3-B5D9-93F6B26BA912 Q38545496-0435D320-44C1-4C23-B829-B2DDE2D3E47B Q41661754-FD2CE215-569E-4AD1-B5BD-C28F307F9FB2 Q45316819-7105BC5D-13C7-41D1-A8EF-0BB460E39527 Q48149753-CFC62007-A01F-453E-827F-4C9B070DBB58 Q52568539-0BC0D031-C834-4A10-9E1B-E8E96F4201D6 Q53821842-79C97934-3529-4A49-9601-E7039BA7F2F5

P2860

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

http://www.wikidata.org/entity/Q37151181

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 28 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@en

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@nl

type

label

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@en

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@nl

prefLabel

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@en

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@nl

P1433

Q37151181-E171D24F-15E7-443B-9E4C-27E04CCEF363

P1476

Q37151181-52D8AA22-C3A9-4693-93B2-A80CCF7DE7AD

P2093

Q37151181-3A6EF72D-87CE-4885-9FFC-3CD06B269B4E

Q37151181-83EEBE00-64A2-4B74-A79C-60D9F662B890

Q37151181-A71EA86F-35CA-4D35-8EF4-12378CB2DBE3

Q37151181-B64E3190-4F76-4738-8307-0CBE7A370EB1

Q37151181-B7EDECD8-A3C5-4E35-A7E1-241D8BE0B58F

Q37151181-C65C4ADA-A9C9-4D50-8253-15E3E08F3C87

P2860

Q37151181-0032621F-C86A-446A-BCAD-339BFE3681DA

Q37151181-017A8479-6B43-4A36-B3EF-C59AB2B17BFA

Q37151181-01AB8822-C514-4F71-844F-766579D20425

Q37151181-068F52A4-4A03-41E8-B19D-ECBBD7C0F59B

Q37151181-12C0AB9F-84D2-42B7-B529-551921CBC27D

Q37151181-333BE8AF-A73A-4D1B-8A28-0FC044A90BE0

Q37151181-35AF1E6C-7943-485F-8285-76E06A2A4D82

Q37151181-366281E2-4BCA-404F-8843-D1720312A0CD

Q37151181-39F469C8-1602-488B-8E02-C55416F95486

Q37151181-412059A0-8F07-483B-AA76-83D6791E6E5F

P304

Q37151181-FD0B1DFB-3346-460A-9B21-A95A9CCB0ACA

P31

Q37151181-4B727CFA-0ECC-4F14-881F-C6DA2B03A4D3

P356

Q37151181-E4845C37-2B2F-4488-AAEC-A94C41AABF70

P407

Q37151181-950C888A-26C9-4AF8-B77D-096568A858B7

P433

Q37151181-10BC012D-1B58-4808-89A5-4896461D9D62

P478

Q37151181-0339D068-ED7A-45B6-9E8C-DA10B02E98F4

P577

Q37151181-0A010367-B397-43B6-B599-2FE9EB703926

P5875

Q37151181-35F2A6B7-DF55-41D8-9E88-B8DC868E7E89

P698

Q37151181-6D1731D8-F1CB-4CC8-854B-43A6520B10BC

P921

Q37151181-87A86C63-5D22-4871-B2D3-A0582B88E95A

P932

Q37151181-9552B5BD-0CA3-442C-A178-E1696FBC3226

P356

BLOOD-2008-06-162248

P1433

P1476

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

@en

P2093

Gary S Stein

http://www.w3.org/2001/XMLSchema#string

Lucio H Castilla

http://www.w3.org/2001/XMLSchema#string

Sayyed K Zaidi

http://www.w3.org/2001/XMLSchema#string

Svetlana Gornostaeva

http://www.w3.org/2001/XMLSchema#string

Toshihisa Komori

http://www.w3.org/2001/XMLSchema#string

Ya-Huei Kuo

http://www.w3.org/2001/XMLSchema#string

P2860

Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner

A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

Control of RUNX2 isoform expression: the role of promoters and enhancers

The RUNX genes: gain or loss of function in cancer

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

P304

3323-3332

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2008-06-162248

http://www.w3.org/2001/XMLSchema#string

P407

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

113

http://www.w3.org/2001/XMLSchema#string

P577

2009-01-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23959404

http://www.w3.org/2001/XMLSchema#string

P698

19179305

http://www.w3.org/2001/XMLSchema#string

P921

P932

2665897

http://www.w3.org/2001/XMLSchema#string