The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. - Wikidata - wikimedia - TriplyDB

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

http://www.wikidata.org/entity/Q37153120

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Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.Maturation of selected human mitochondrial tRNAs requires deadenylation.Neuroketotherapeutics: A modern review of a century-old therapy.Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome.Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.TDP-43 stabilises the processing intermediates of mitochondrial transcripts.TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma.Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.Genetic mutations in RNA-binding proteins and their roles in ALS.New Therapeutic Avenue for ALS: Avoiding a Fatal Encounter of TDP-43 at the Mitochondria.Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms.Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications.TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.Metal complexes for multimodal imaging of misfolded protein-related diseases.Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex.Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.Use of ade1 and ade2 mutations for development of a versatile red/white colour assay of amyloid-induced oxidative stress in saccharomyces cerevisiae.Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities.TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease.An in vitro model yields 'importin' new insights into chronic traumatic encephalopathy: damaged astrocytes stop 'thrombospondin' to the injury: An Editorial Highlight for 'Defective synthesis and release of astrocytic thrombospondin-1 mediates the n Cytoplasmic functions of long noncoding RNAs.Pathomechanisms of TDP-43 in neurodegeneration.Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?Stroke recovery and rehabilitation in 2016: a year in review of basic science and clinical science.Amyotrophic lateral sclerosis Emerging roles of mitochondria in synaptic transmission and neurodegeneration Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors

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The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

http://www.wikidata.org/entity/Q37153120

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 June 2016

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@en

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@nl

type

label

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@en

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@nl

prefLabel

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@en

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

@nl

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Nature Medicine

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The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.

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Heewon Choi

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Hisashi Fujioka

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Hu Li

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Jingjing Liang

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Luwen Wang

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Max Sheng

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Paul H Lerou

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Sandra L Siedlak

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Sirui Jiang

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Xiaopin Ma

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De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

Locating proteins in the cell using TargetP, SignalP and related tools

Computational method to predict mitochondrially imported proteins and their targeting sequences

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10.1038/NM.4130

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Edroaldo Lummertz da Rocha

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