De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.
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New horizons for host defense peptides and lantibioticsPeptidomimetics as a new generation of antimicrobial agents: current progressMembrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibioticsAntibiotics in the clinical pipeline at the end of 2015.De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities.Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedronDe novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.Expedient Synthesis of SMAMPs via Click Chemistry.A miniature mimic of host defense peptides with systemic antibacterial efficacy.Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranesComparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16.Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasisScreen for agents that induce autolysis in Bacillus subtilis.Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics.Antibacterial studies of cationic polymers with alternating, random, and uniform backbones.The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides.Intrinsic Folding Proclivities in Cyclic β-Peptide Building Blocks: Configuration and Heteroatom Effects Analyzed by Conformer-Selective Spectroscopy and Quantum Chemistry.Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers.Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin.Synthetic mimics of antimicrobial peptides with immunomodulatory responsesCalcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity.A critical evaluation of random copolymer mimesis of homogeneous antimicrobial peptidesNylon-3 polymers with selective antifungal activityIdentification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold.Structure and Function of AApeptides.Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffoldBeta-peptoid "foldamers"--why the additional methylene unit?Recent synthetic transport systems.Fluorine: a new element in protein design.Recent development of small antimicrobial peptidomimetics.AApeptides as a new class of antimicrobial agents.Natural product and natural product derived drugs in clinical trials.Antimicrobial γ-AApeptides (WO2013112548): a patent evaluation.Poly(ethylene imine)s as antimicrobial agents with selective activity.An overview of peptide and peptoid foldamers in medicinal chemistry.Antibacterial mechanism of action of arylamide foldamers.
P2860
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P2860
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
De novo design and in vivo act ...... microbial arylamide foldamers.
@en
De novo design and in vivo act ...... microbial arylamide foldamers.
@nl
type
label
De novo design and in vivo act ...... microbial arylamide foldamers.
@en
De novo design and in vivo act ...... microbial arylamide foldamers.
@nl
prefLabel
De novo design and in vivo act ...... microbial arylamide foldamers.
@en
De novo design and in vivo act ...... microbial arylamide foldamers.
@nl
P2093
P2860
P356
P1476
De novo design and in vivo act ...... microbial arylamide foldamers.
@en
P2093
Andre Isaacs
Dylan Clements
Hyemin Kim
Jeffrey D Winkler
Richard W Scott
Sungwook Choi
P2860
P304
P356
10.1073/PNAS.0811818106
P407
P577
2009-04-09T00:00:00Z