Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
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Insulin as a key autoantigen in the development of type 1 diabetesCompensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responsesT cells recognizing a peptide contaminant undetectable by mass spectrometry.Therapeutic targeting of Syk in autoimmune diabetesA missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific mannerInhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideIslet autoantigens: structure, function, localization, and regulation.Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells.Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.Wnt signaling inhibits CTL memory programming.Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Recent Advances in Astragalus membranaceus Anti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents.Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for ToleranceImmunological pathways to β-cell damage in Type 1 diabetes.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes.Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice.Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.Tracking Immunological Responses of Islet Antigen-Specific T Cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes.Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex.Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice.
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P2860
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 10 February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@en
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@nl
type
label
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@en
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@nl
prefLabel
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@en
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@nl
P2093
P2860
P356
P1433
P1476
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.
@en
P2093
Christophe Viret
F Susan Wong
Gwen Scott
Ian J Thomas
Lai Khai Siew
Stephen Chapman
P2860
P304
P356
10.2337/DB08-0800
P407
P577
2009-02-10T00:00:00Z