Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. - Wikidata - wikimedia - TriplyDB

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

http://www.wikidata.org/entity/Q37163535

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Insulin as a key autoantigen in the development of type 1 diabetes Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses T cells recognizing a peptide contaminant undetectable by mass spectrometry.Therapeutic targeting of Syk in autoimmune diabetes A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide Islet autoantigens: structure, function, localization, and regulation.Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells.Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.Wnt signaling inhibits CTL memory programming.Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Recent Advances in Astragalus membranaceus Anti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents.Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for Tolerance Immunological pathways to β-cell damage in Type 1 diabetes.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes.Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6 Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice.Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.Tracking Immunological Responses of Islet Antigen-Specific T Cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes.Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex.Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice.

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Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

http://www.wikidata.org/entity/Q37163535

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@en

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

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type

label

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@en

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@nl

prefLabel

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@en

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@nl

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Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

@en

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Christophe Viret

http://www.w3.org/2001/XMLSchema#string

F Susan Wong

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Gwen Scott

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Ian J Thomas

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Lai Khai Siew

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Li Wen

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Stephen Chapman

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P2860

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Projection of an immunological self shadow within the thymus by the aire protein

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.

Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.

Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes.

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus

T cell tolerance and autoimmunity.

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1156-1164

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scholarly article

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10.2337/DB08-0800

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2009-02-10T00:00:00Z

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19208910

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