Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct.
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Gold compounds as therapeutic agents for human diseasesAuranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strainsA reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lambliaA selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.Exposure to silver nanoparticles inhibits selenoprotein synthesis and the activity of thioredoxin reductaseAntibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Luminescent di- and polynuclear organometallic gold(I)-metal (Au2, {Au2Ag}n and {Au2Cu}n) compounds containing bidentate phosphanes as active antimicrobial agents.Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 PathwayLeishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections.Proline-dependent regulation of Clostridium difficile Stickland metabolism.Repurposing auranofin for the treatment of cutaneous staphylococcal infections.Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.Targeting selenium metabolism and selenoproteins: novel avenues for drug discoveryThe biological activity of auranofin: implications for novel treatment of diseases.Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin.Gold(I) complexes of water-soluble diphos-type ligands: synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition.Australasian Society of Infectious Diseases updated guidelines for the management of Clostridium difficile infection in adults and children in Australia and New Zealand.Inhibition of selenium metabolism in the oral pathogen Treponema denticola.Auranofin: repurposing an old drug for a golden new age.The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotypeBetter living through chemistry: Addressing emerging antibiotic resistance.Uptake and Utilization of Selenium from Selenoprotein P.Developmental toxicity of auranofin in zebrafish embryos.Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo.Protein-Derived Cofactors Revisited: Empowering Amino Acid Residues with New Functions.Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections.Novel Antimicrobials for the Treatment of Clostridium difficile Infection.Gold-Based Therapeutic Agents: A New PerspectivePara-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria
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P2860
Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@en
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@nl
type
label
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@en
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@nl
prefLabel
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@en
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct.
@nl
P2093
P2860
P1476
Auranofin disrupts selenium me ...... forming a stable Au-Se adduct
@en
P2093
Andrew Myers
Darin Cowart
Rebecca Tarrien
Rodney L Levine
Sarah Jackson-Rosario
P2860
P2888
P304
P356
10.1007/S00775-009-0466-Z
P577
2009-01-23T00:00:00Z