Aminoacylating urzymes challenge the RNA world hypothesis
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Urzymology: experimental access to a key transition in the appearance of enzymesWhat RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental AttentionFunctional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same GeneCoevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic LifeHow amino acids and peptides shaped the RNA worldThe place of RNA in the origin and early evolution of the genetic machinerySynergism and mutualism in non-enzymatic RNA polymerizationThe Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement without Ordered Ground-State Tertiary Structures.High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine.tRNA acceptor stem and anticodon bases form independent codes related to protein folding.tRNA acceptor-stem and anticodon bases embed separate features of amino acid chemistry.Full implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular couplingEnzyme recruitment and its role in metabolic expansion.The ribosome challenge to the RNA world.A modified PATH algorithm rapidly generates transition states comparable to those found by other well established algorithms.Predicting the pathogenicity of aminoacyl-tRNA synthetase mutations.The Hypothesis that the Genetic Code Originated in Coupled Synthesis of Proteins and the Evolutionary Predecessors of Nucleic Acids in Primitive Cells.Autocatalytic sets in a partitioned biochemical network.Thermal Condensation of Glycine and Alanine on Metal Ferrite Surface: Primitive Peptide Bond Formation Scenario.Spontaneous mutual ordering of nucleic acids and proteins.Evolutionary importance of the intramolecular pathways of hydrolysis of phosphate ester mixed anhydrides with amino acids and peptides.The generation of meaningful information in molecular systems.Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding.Computational design of fully overlapping coding schemes for protein pairs and triplets.Autocatalytic Sets and RNA Secondary Structure.Coding of Class I and II Aminoacyl-tRNA Synthetases.Nontemplate-driven polymers: clues to a minimal form of organization closure at the early stages of living systems.The Emergence of the First Cells
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Aminoacylating urzymes challenge the RNA world hypothesis
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Aminoacylating urzymes challenge the RNA world hypothesis
@en
Aminoacylating urzymes challenge the RNA world hypothesis.
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type
label
Aminoacylating urzymes challenge the RNA world hypothesis
@en
Aminoacylating urzymes challenge the RNA world hypothesis.
@nl
prefLabel
Aminoacylating urzymes challenge the RNA world hypothesis
@en
Aminoacylating urzymes challenge the RNA world hypothesis.
@nl
P2093
P2860
P356
P1476
Aminoacylating urzymes challenge the RNA world hypothesis
@en
P2093
Charles W Carter
Christopher Francklyn
P2860
P304
26856-26863
P356
10.1074/JBC.M113.496125
P407
P577
2013-07-18T00:00:00Z