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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

http://www.wikidata.org/entity/Q37169972

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The notch ligand JAGGED1 as a target for anti-tumor therapy Notch Signaling in Neuroendocrine Tumors Cancer stem cells in small cell lung cancer Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives Cancer stem cell division: when the rules of asymmetry are broken Molecular mechanisms of epithelial-mesenchymal transition ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition Breast cancer brain metastases: biology and new clinical perspectives Role of epithelial-mesenchymal transition in gastric cancer initiation and progression HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.Expression of Notch Gene and Its Impact on Survival of Patients with Resectable Non-small Cell Lung Cancer.Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer.Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer.βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin.SNAI2/Slug gene is silenced in prostate cancer and regulates neuroendocrine differentiation, metastasis-suppressor and pluripotency gene expression.The role of adipose-derived stem cells in breast cancer progression and metastasis.Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells.Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1 DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis.Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer.Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.From molecular interaction to acute promyelocytic leukemia: Calculating leukemogenesis and remission from endogenous molecular-cellular network.Oncogenic role of the Notch pathway in primary liver cancer.The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.Role of Notch signaling pathway in pancreatic cancer.miR-494-3p is a novel tumor driver of lung carcinogenesis.Significance of glycosylation in Notch signaling.Pancreatic cancer stem cells.A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma.Lateral inhibition of Notch signaling in neoplastic cells.Exploiting Gene Expression Kinetics in Conventional Radiotherapy, Hyperfractionation, and Hypofractionation for Targeted Therapy.The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells.

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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

http://www.wikidata.org/entity/Q37169972

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 September 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

@en

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.

@nl

type

label

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

@en

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.

@nl

prefLabel

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

@en

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.

@nl

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OncoTargets and Therapy

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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

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Fei Xing

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Ingrid Espinoza

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Kounosuke Watabe

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P2860

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

Mammary stem cells, self-renewal pathways, and carcinogenesis

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

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1249-1259

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scholarly article

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10.2147/OTT.S36162

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6

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Radhika Pochampally

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2013-09-06T00:00:00Z

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24043949

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3772757

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