Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
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Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediatesA neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferaseStructural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme IntermediateGlucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic α-amylaseSuite of activity-based probes for cellulose-degrading enzymesIn cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 gangliosideBiomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies.Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4'-deoxy-4'-fluoro-Thomsen-Friedenreich epitope.Synthesis of a pseudo-disaccharide library and its application to the characterisation of the heparanase catalytic siteThiogalactopyranosides are resistant to hydrolysis by α-galactosidases.Chemical approaches to perturb, profile, and perceive glycans.Glycosphingolipids--nature, function, and pharmacological modulation.Glycosidase inhibition: assessing mimicry of the transition state.Applications of azide-based bioorthogonal click chemistry in glycobiology.Polysaccharide-based micelles for drug delivery.The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience.Dissecting conformational contributions to glycosidase catalysis and inhibition.The rise and fall of poly(ADP-ribose): An enzymatic perspective.Current and Novel Aspects on the Non-lysosomal β-Glucosylceramidase GBA2.Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis.Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes.Structure activity relationships of N-linked and diglycosylated glucosamine-based antitumor glycerolipids.Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors.From covalent glycosidase inhibitors to activity-based glycosidase probes.Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.Structural Dissection of the Maltodextrin Disproportionation Cycle of the Arabidopsis Plastidial Disproportionating Enzyme 1 (DPE1).1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase InhibitorSynthesis and analysis of specific covalent inhibitors of endo-xyloglucanases.Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.Macrocyclic mechanism-based inhibitor for neuraminidases.A new approach in the active site investigation of an inverting β-D-xylosidase from Thermobifida fusca TM51.Base-catalyzed diastereoselective trimerization of trifluoroacetone.The effect of a covalent and a noncovalent small-molecule inhibitor on the structure of Abg β-glucosidase in the gas-phase.Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors.Mass spectrometric study of gas-phase ions of acid β-glucosidase (Cerezyme) and iminosugar pharmacological chaperones.A general method for affinity-based proteomic profiling of exo-α-glycosidases.Biochemical Characterization of the c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic AtaxiaRapid phenolic O-glycosylation of small molecules and complex unprotected peptides in aqueous solvent
P2860
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P2860
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@en
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@nl
type
label
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@en
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@nl
prefLabel
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@en
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@nl
P2860
P356
P1433
P1476
Covalent inhibitors of glycosidases and their applications in biochemistry and biology.
@en
P2093
Brian P Rempel
Stephen G Withers
P2860
P304
P356
10.1093/GLYCOB/CWN041
P577
2008-05-22T00:00:00Z