Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
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Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaPresenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathwayNuclear BK channels regulate gene expression via the control of nuclear calcium signaling.Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse modelAPP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.Mediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem CellsDe novo variants in sporadic cases of childhood onset schizophrenia.Presenilin-ryanodine receptor connection.Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral.Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals.Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?Neuronal Ryanodine Receptors in Development and Aging.Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.Molecular and functional identification of a mitochondrial ryanodine receptor in neurons.AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases?Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1.Presenilins as Drug Targets for Alzheimer's Disease-Recent Insights from Cell Biology and Electrophysiology as Novel Opportunities in Drug Development.Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease
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Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
@en
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
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type
label
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
@en
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
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prefLabel
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
@en
Presenilins regulate calcium h ...... eptors in hippocampal neurons.
@nl
P2093
P2860
P356
P1476
Presenilins regulate calcium h ...... ceptors in hippocampal neurons
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P2093
P2860
P304
15091-15096
P356
10.1073/PNAS.1304171110
P407
P50
P577
2013-08-05T00:00:00Z