Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism. - Wikidata - wikimedia - TriplyDB

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

http://www.wikidata.org/entity/Q37175099

about

Pharmacological chaperoning: a primer on mechanism and pharmacology High-content screening identifies a role for Na(+) channels in insulin production Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Congenital hyperinsulinism: current status and future perspectives.Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.Pharmacological correction of misfolding of ABC proteins.Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8.The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology.Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP.Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11.Pharmacological Chaperones: Beyond Conformational Disorders.Monitoring Changes in the Abundance of Endogenously Expressed ATP-Sensitive Potassium (KATP) Channels in the Plasma Membrane Using Surface Biotinylation.Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice.Network-based approach to prediction and population-based validation of in silico drug repurposing.

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Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

http://www.wikidata.org/entity/Q37175099

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 06 June 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@en

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@nl

type

label

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@en

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@nl

prefLabel

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@en

Carbamazepine as a novel small ...... in congenital hyperinsulinism.

@nl

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JBC.M113.470948

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Journal of Biological Chemistry

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Carbamazepine as a novel small ...... in congenital hyperinsulinism

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P2093

Erik M Olson

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Heidi M Sampson

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Qing Zhou

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Show-Ling Shyng

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Yelena Kryukova

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism

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Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex

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10.1074/JBC.M113.470948

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David Y. Thomas

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