Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
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Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progressThe Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac developmentIntracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyaseTransforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.Role of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxinThe impact of sphingosine kinase-1 in head and neck cancer.Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis?Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.Role of host sphingosine kinase 1 in the lung response against Cryptococcosis.A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disordersLysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblastsProlonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.Paracrine mechanisms of stem cell reparative and regenerative actions in the heartDihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levelsRegulating survival and development in the retina: key roles for simple sphingolipids.Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationSphingolipids in pulmonary fibrosis.Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model.Vascular involvement in systemic sclerosis (scleroderma).Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation.Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts.Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer.Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signalingImplication of sphingosin-1-phosphate in cardiovascular regulation.Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cellsSphingosine-1-phosphate receptor signalling in the heart.Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.Sphingolipid regulation of tissue fibrosisIdentification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis.Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma.Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells.Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis.Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis.Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model.Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic studySphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy.
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Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Sphingosine-1-phosphate and sp ...... duction by cardiac fibroblasts
@en
Sphingosine-1-phosphate and sp ...... uction by cardiac fibroblasts.
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type
label
Sphingosine-1-phosphate and sp ...... duction by cardiac fibroblasts
@en
Sphingosine-1-phosphate and sp ...... uction by cardiac fibroblasts.
@nl
prefLabel
Sphingosine-1-phosphate and sp ...... duction by cardiac fibroblasts
@en
Sphingosine-1-phosphate and sp ...... uction by cardiac fibroblasts.
@nl
P2093
P2860
P356
P1476
Sphingosine-1-phosphate and sp ...... duction by cardiac fibroblasts
@en
P2093
James S Swaney
Kelli M Moreno
Nicole Gellings Lowe
Roger A Sabbadini
P2860
P304
P356
10.1093/CVR/CVP056
P577
2009-02-19T00:00:00Z