Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. - Wikidata - wikimedia - TriplyDB

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

http://www.wikidata.org/entity/Q37178911

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An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 OTUB1 modulates c-IAP1 stability to regulate signalling pathways The Ubiquitination of NF-κB Subunits in the Control of Transcription DED or alive: assembly and regulation of the death effector domain complexes Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation Clinical implications of the molecular genetics of chronic lymphocytic leukemia Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions The two faces of receptor interacting protein kinase-1 Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)IAPs: a central element in the NF-κB activating signaling pathway Roles of TRAF3 in T cells: many surprises Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2 Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis Regulation of tumour necrosis factor signalling: live or let die OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3 NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target c-IAP1 and c-IAP2 redundancy differs between T and B cells.Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.Signaling to NF-kappaB: regulation by ubiquitination.Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling.NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.Classical and/or alternative NF-kappaB pathway activation in multiple myeloma.Oncogenic activation of NF-kappaB.TRAF3 regulates homeostasis of CD8+ central memory T cells.Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Structural Basis for the Activation of IKK1/α SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells.Translational studies in older men using testosterone to treat sarcopenia.Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells

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P2860

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

http://www.wikidata.org/entity/Q37178911

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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type

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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Nature Immunology

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Noncanonical NF-kappaB activat ...... and TRAF3 and the kinase NIK.

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P2093

Brian J Zarnegar

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Douglas J Mahoney

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Herman H Cheung

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Jeannie He

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Paul W Dempsey

http://www.w3.org/2001/XMLSchema#string

Robert G Korneluk

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Tak W Mak

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Travis Shiba

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Wen-Chen Yeh

http://www.w3.org/2001/XMLSchema#string

Xiaolu Yang

http://www.w3.org/2001/XMLSchema#string

P2860

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

CD40 regulates the processing of NF-kappaB2 p100 to p52

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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1371-1378

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10.1038/NI.1676

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12

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9

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23462309

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1053487240

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18997794

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2676931

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