about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognitionMethotrexate Is a JAK/STAT Pathway InhibitorCeramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent MannerA hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisHydroxyethyl starch as an effective methotrexate carrier in anticancer therapy.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Glucose conjugation for the specific targeting and treatment of cancer.The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitorTumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyGlucarpidase (voraxaze), a carboxypeptidase enzyme for methotrexate toxicity.Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line.Clinical presentation and protocol for management of hepatic sarcoidosis.Apoptosis and associated phenomena as a determinants of the efficacy of photodynamic therapy.Antivitamins for Medicinal Applications.Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype.Chemotherapy and Transplantation: The Role of Immunosuppression in Malignancy and a Review of Antineoplastic Agents in Solid Organ Transplant Recipients.Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment.Cancer Metabolism: Fueling More than Just GrowthAlterations in the expression pattern of MTHFR, DHFR, TYMS, and SLC19A1 genes after treatment of laryngeal cancer cells with high and low doses of methotrexate.Methotrexate toxicity treated with continuous venovenous hemofiltration, leucovorin and glucarpidaseThe impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitroType 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage.Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.Metabolic Enzymes in Sarcomagenesis: Progress Toward Biology and Therapy.Overexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The antifolates
@en
The antifolates.
@nl
type
label
The antifolates
@en
The antifolates.
@nl
prefLabel
The antifolates
@en
The antifolates.
@nl
P2093
P2860
P1476
The antifolates
@en
P2093
I David Goldman
Michele Visentin
Rongbao Zhao
P2860
P304
629-48, ix
P356
10.1016/J.HOC.2012.02.002
P577
2012-06-01T00:00:00Z