Toll-like receptor signalling on Tregs: to suppress or not to suppress?
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Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responsesTreg functional stability and its responsiveness to the microenvironmentThe immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cellsFoxp3+ regulatory T cells are required for recovery from severe sepsisInducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiotaCurrent status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice.Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways.CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists.Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunityOral bacteria induce a differential activation of human immunodeficiency virus-1 promoter in T cells, macrophages and dendritic cells.Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gutDistinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammationTranslating tumor antigens into cancer vaccinesEngagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.The TLR7 agonist induces tumor regression both by promoting CD4⁺T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells.Hepatocellular carcinoma and macrophage interaction induced tumor immunosuppression via Treg requires TLR4 signaling.The role of natural regulatory T cells in infection.Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathwayThe role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways.Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells.Regulatory T cells as therapeutic targets in rheumatoid arthritis.Overcoming tumor-mediated immunosuppression.MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver.Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger SignalsInfluence of tumors on protective anti-tumor immunity and the effects of irradiation.Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes.IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis.The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.Regulatory T cell subsets in peripheral blood of celiac disease patients and TLR2 expression: correlation with oxidative stress.
P2860
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P2860
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@en
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
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type
label
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@en
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@nl
prefLabel
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@en
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@nl
P2093
P2860
P1433
P1476
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
@en
P2093
Gosse J Adema
I Jolanda M de Vries
Wendy W C van Maren
P2860
P304
P356
10.1111/J.1365-2567.2008.02871.X
P577
2008-06-28T00:00:00Z