A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.
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Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and GiardiaA review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapyIdentification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lambliaA high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosisBumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.Treatment of Cryptosporidium: What We Know, Gaps, and the Way ForwardTheileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitorThe gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites.Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum.Allosteric activation of apicomplexan calcium-dependent protein kinases.In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninumA Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.INTESTINAL AND PULMONARY INFECTION BY Cryptosporidium parvum IN TWO PATIENTS WITH HIV/AIDSReview of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Killing of Cryptosporidium sporozoites by Lactoferrin.Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture.Drug target identification in protozoan parasites.Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.The in vitro and ex vivo effect of Auranta 3001 in preventing Cryptosporidium hominis and Cryptosporidium parvum infection.5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.Addressing Cryptosporidium Infection among Young Children in Low-Income Settings: The Crucial Role of New and Existing Drugs for Reducing Morbidity and Mortality.A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open Access Malaria Box.Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.In vitro growth inhibition of Theileria equi by bumped kinase inhibitors.The existing drug vorinostat as a new lead against cryptosporidiosis by targeting the parasite histone deacetylases.A novel CDPK1 inhibitor--a potential treatment for cryptosporidiosis in calves?
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A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 21 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@en
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@nl
type
label
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@en
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@nl
prefLabel
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@en
A novel calcium-dependent prot ...... or treating cryptosporidiosis.
@nl
P2093
P2860
P50
P356
P1476
A novel calcium-dependent prot ...... for treating cryptosporidiosis
@en
P2093
Alejandro Castellanos-Gonzalez
Anna M W Fox
Ayesha Irani
Erkang Fan
Kasey Rivas
Katelyn R Keyloun
Kayode K Ojo
Molly C Reid
Rama S R Vidadala
Wesley C Van Voorhis
P2860
P304
P356
10.1093/INFDIS/JIT327
P407
P577
2013-07-21T00:00:00Z