An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer - Wikidata - wikimedia - TriplyDB

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

http://www.wikidata.org/entity/Q37187915

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Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation Shepherding AKT and androgen receptor by Ack1 tyrosine kinase Should individual PI3 kinase isoforms be targeted in cancer?Rak functions as a tumor suppressor by regulating PTEN protein stability and function PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection The mTOR signalling pathway in human cancer Comprehensive molecular portraits of human breast tumours Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer Targeting the mTOR signaling network for cancer therapy PI3K/Akt/mTOR inhibitors in breast cancer PI3K and AKT: Unfaithful Partners in Cancer The PI3K/AKT Pathway and Renal Cell Carcinoma What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer Clinical evidence of the efficacy of everolimus and its potential in the treatment of breast cancer Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy Signaling cross-talk in the resistance to HER family receptor targeted therapy Posttranslational regulation of Akt in human cancer Optimal experimental design for parameter estimation of a cell signaling model MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors Therapeutic targeting of cancers with loss of PTEN function.The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors Developmental therapeutics for inflammatory breast cancer: Biology and translational directions PI3K mutations in breast cancer: prognostic and therapeutic implications Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data Oncogenic mutations of PIK3CA in human cancers Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling Next generation MUT-MAP, a high-sensitivity high-throughput microfluidics chip-based mutation analysis panel High-Throughput Mutation Profiling Changes before and 3 Weeks after Chemotherapy in Newly Diagnosed Breast Cancer Patients Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases Targeting the phosphoinositide 3-kinase pathway in cancer Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

http://www.wikidata.org/entity/Q37187915

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on August 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

An integrative genomic and pro ...... AKT mutations in breast cancer

@en

An integrative genomic and pro ...... KT mutations in breast cancer.

@nl

type

label

An integrative genomic and pro ...... AKT mutations in breast cancer

@en

An integrative genomic and pro ...... KT mutations in breast cancer.

@nl

prefLabel

An integrative genomic and pro ...... AKT mutations in breast cancer

@en

An integrative genomic and pro ...... KT mutations in breast cancer.

@nl

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0008-5472.CAN-07-6854

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Cancer Research

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An integrative genomic and pro ...... AKT mutations in breast cancer

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Ana Lluch

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Ana Maria Gonzalez-Angulo

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Aysegul Sahin

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Bryan T Hennessy

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Gordon B Mills

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Hugo Horlings

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Joe W Gray

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Katrien Berns

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Lajos Pusztai

http://www.w3.org/2001/XMLSchema#string

Laura K Nolden

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P2860

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

The consensus coding sequences of human breast and colorectal cancers

High frequency of mutations of the PIK3CA gene in human cancers

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

Patterns of somatic mutation in human cancer genomes

Exploiting the PI3K/AKT pathway for cancer drug discovery

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6084-6091

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scholarly article

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10.1158/0008-5472.CAN-07-6854

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15

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68

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Marc van de Vijver

Katherine Stemke-Hale

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2008-08-01T00:00:00Z

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18676830

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2680495

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