Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.
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Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPKThe Borg family of Cdc42 effector proteins Cdc42EP1-5A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in DrosophilaErk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.Mitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.ERK as a model for systems biology of enzyme kinetics in cells.Emerging technologies to map the protein methylome.Expanding applications of chemical genetics in signal transduction.Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functionsFrequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes.Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics.Building robust transcriptomes with master splicing factorsmiR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2.LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells.Empirical inference of circuitry and plasticity in a kinase signaling networkGain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.Analysing signalling networks by mass spectrometry.Stimulated nuclear import by β-like importins.System level dynamics of post-translational modifications.A compendium of ERK targets.Protein-protein interactions in plant mitogen-activated protein kinase cascades.Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.ERK Plays a Role in Chromosome Alignment and Participates in M-Phase Progression.Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer.Co-culture Activation of MAP Kinase in Drosophila S2 Cells.DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling.Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases.Labeling and identification of direct kinase substratesComparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells.A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer.Specificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells.
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Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 25 October 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@en
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
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type
label
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@en
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@nl
prefLabel
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@en
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@nl
P2093
P2860
P1433
P1476
Large-scale discovery of ERK2 ...... criptional regulation by ETV3.
@en
P2093
Adam Labadorf
Candace R Chouinard
Carol J Lam
Ernest Fraenkel
Forest M White
Katrin Schmelzle
Scott M Carlson
P2860
P356
10.1126/SCISIGNAL.2002010
P577
2011-10-25T00:00:00Z