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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

http://www.wikidata.org/entity/Q37195037

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Aging of blood can be tracked by DNA methylation changes at just three CpG sites Epigenetic modulators, modifiers and mediators in cancer aetiology and progression DNA methylation and healthy human aging New Insights for Oxidative Stress and Diabetes Mellitus Epigenetic regulation of Keap1-Nrf2 signaling Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver The cerebellum ages slowly according to the epigenetic clock Longitudinal Effects of Developmental Bisphenol A and Variable Diet Exposures on Epigenetic Drift in Mice An epigenetic aging clock for dogs and wolves.Age-associated chromatin relaxation is enhanced in Huntington's disease mice.Comparison of different cell type correction methods for genome-scale epigenetics studies.DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing Longitudinal epigenetic drift in mice perinatally exposed to lead.Obesity accelerates epigenetic aging of human liver.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Emerging issues in public health genomics.Epigenetic clock analyses of cellular senescence and ageing Discordance of DNA methylation variance between two accessible human tissues.Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes.Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin Concordant and discordant DNA methylation signatures of aging in human blood and brain.Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation Epigenetic Aging Signatures Are Coherently Modified in Cancer Impact of a folic acid-enriched diet on urinary tract function in mice treated with testosterone and estradiol.SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing.DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging.A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers.A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation Genetic and environmental influences interact with age and sex in shaping the human methylome.Epigenetic assimilation in the aging human brain

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

http://www.wikidata.org/entity/Q37195037

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article científic

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bilimsel makale

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scientific article published on 04 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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type

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Human Molecular Genetics

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Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

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Andrew E Teschendorff

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James West

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Stephan Beck

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Creative Commons Attribution 3.0 Unported

P2860

Epigenetic predictor of age

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

DNA Damage, Aging, and Cancer

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms

Epigenetic differences arise during the lifetime of monozygotic twins

Distinct DNA methylomes of newborns and centenarians

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Human DNA methylomes at base resolution show widespread epigenomic differences

Intra-individual change over time in DNA methylation with familial clustering

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scholarly article

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10.1093/HMG/DDT375

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2013-08-04T00:00:00Z

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2013-10-15T00:00:00Z

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255690349

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23918660

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regulation of gene expression

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3782071

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