Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. - Wikidata - wikimedia - TriplyDB

Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.

Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.

http://www.wikidata.org/entity/Q37198187

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The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer.Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation.The role of COX-2 in intestinal inflammation and colorectal cancer Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis.Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis.Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)PPARδ and PGE2 signaling pathways communicate and connect inflammation to colorectal cancer Establishing the Role of PPARβ/δ in Carcinogenesis The role of peroxisome proliferator-activated receptors in colorectal cancer.Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer.β-Catenin and peroxisome proliferator-activated receptor-δ coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells.Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?High-fat diet enhances stemness and tumorigenicity of intestinal progenitors PPARδ promotes oncogenic redirection of TGF-β1 signaling through the activation of the ABCA1-Cav1 pathway.PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.Targeting the LKB1 tumor suppressor.Metastasis regulation by PPARD expression in cancer cells.Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer.Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention.PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells.ALOX15 as a suppressor of inflammation and cancer: Lost in the link.Transcription factor AP1 binds the functional region of the promoter and regulates gene expression of human PPARdelta in LoVo cell.Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ Pathway.Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.Peroxisome proliferator-activated receptors (PPARs) are potential drug targets for cancer therapy Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia.ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.HBXIP activates the PPARδ/NF-κB feedback loop resulting in cell proliferation.

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Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.

http://www.wikidata.org/entity/Q37198187

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article científic

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bilimsel makale

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scientific article published on 12 May 2009

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vedecký článok

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Journal of the National Cancer Institute

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Targeted genetic disruption of ...... lta and colonic tumorigenesis.

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Imad Shureiqi

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Jeffrey S Morris

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Micheline J Moussalli

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Russell R Broaddus

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Susan M Fischer

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Xiangsheng Zuo

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Zhanglong Peng

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P2860

The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

Critical roles of PPAR beta/delta in keratinocyte response to inflammation

Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.

Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.

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762-767

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10.1093/JNCI/DJP078

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10

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101

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24421465

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19436036

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2684551

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