The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.
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Initial events in bacterial transcription initiationBacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug ActionFRETBursts: An Open Source Toolkit for Analysis of Freely-Diffusing Single-Molecule FRETSingle-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.Biochemical insights into the function of phage G1 gp67 in Staphylococcus aureus.Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection.Mesoscopic model and free energy landscape for protein-DNA binding sites: analysis of cyanobacterial promoters.Base flipping in open complex formation at bacterial promotersMassively Systematic Transcript End Readout, "MASTER": Transcription Start Site Selection, Transcriptional Slippage, and Transcript Yields.Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selectionFörster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulersTSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens.Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcriptionStudying transcription initiation by RNA polymerase with diffusion-based single-molecule fluorescence.Open complex scrunching before nucleotide addition accounts for the unusual transcription start site of E. coli ribosomal RNA promoters.What have single-molecule studies taught us about gene expression?RNA Polymerase Pausing during Initial Transcription.RNA polymerase: in search of promoters.Single-molecule methods to study membrane receptor oligomerization.How to switch the motor on: RNA polymerase initiation steps at the single-molecule level.Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA.Single-molecule tracking of the transcription cycle by sub-second RNA detection.An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity.Caging and Photoactivation in Single-Molecule Förster Resonance Energy Transfer Experiments.The mechanism of variability in transcription start site selection.Direct observation of breathing dynamics at the mismatch induced DNA bubble with nanometre accuracy: a smFRET study.Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes.Open complex DNA scrunching: A key to transcription start site selection and promoter escape.Characterizing highly dynamic conformational states: The transcription bubble in RNAP-promoter open complex as an example.Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria.
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P2860
The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 December 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The transcription bubble of th ...... cription start-site selection.
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The transcription bubble of th ...... cription start-site selection.
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The transcription bubble of th ...... cription start-site selection.
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The transcription bubble of th ...... cription start-site selection.
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The transcription bubble of th ...... cription start-site selection.
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The transcription bubble of th ...... cription start-site selection.
@nl
P2093
P2860
P50
P1476
The transcription bubble of th ...... cription start-site selection.
@en
P2093
Achillefs N Kapanidis
Diego Duchi
Kristofer Gryte
Ling Chin Hwang
Nicole C Robb
Yusdi Santoso
P2860
P304
P356
10.1016/J.JMB.2012.12.015
P407
P577
2012-12-28T00:00:00Z