Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)
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MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture.Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.
P2860
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 August 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Structural basis of HIV inhibi ...... luoro-2'-deoxyadenosine (EFdA)
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Structural basis of HIV inhibi ...... nyl-2-fluoro-2'-deoxyadenosine
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Structural basis of HIV inhibi ...... luoro-2'-deoxyadenosine (EFdA)
@en
Structural basis of HIV inhibi ...... nyl-2-fluoro-2'-deoxyadenosine
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prefLabel
Structural basis of HIV inhibi ...... luoro-2'-deoxyadenosine (EFdA)
@en
Structural basis of HIV inhibi ...... nyl-2-fluoro-2'-deoxyadenosine
@nl
P2093
P2860
P356
P1476
Structural basis of HIV inhibi ...... luoro-2'-deoxyadenosine (EFdA)
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P2093
Bruno Marchand
Eiichi N Kodama
Hiroaki Mitsuya
Kamalendra Singh
Karen A Kirby
Lisa C Rohan
Michael A Parniak
Stefan G Sarafianos
P2860
P304
P356
10.1073/PNAS.1605223113
P407
P577
2016-08-03T00:00:00Z